APOE and immunity: Research highlights

Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K.L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. NielsenKellen K. Petersen, Melissa Petersen, Stefanie D. Piña-Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia Tcw, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L. Worley, Henrik Zetterberg, Maria C. Carrillo

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.

Original languageEnglish
Pages (from-to)2677-2696
Number of pages20
JournalAlzheimer's and Dementia
Issue number6
StatePublished - Jun 2023

Bibliographical note

Funding Information:
The authors would like to thank and acknowledge all conference organizers, speakers, and session chairs for your tremendous contributions to this conference. The authors would also like to thank Joanna Graca at the Alzheimer's Association for her work on this article. Courtney M. Kloske is a full-time employee of the Alzheimer's Association. Christopher J. Barnum reports in the past 36 months, grants or contracts from Alzheimer's Association, ALS Association, and the National Institutes of Health (NIH); and holds multiple patents surrounding treating neurodegenerative disease with TNF inhibitors. Andre F. Batista has nothing to disclose. Elizabeth M. Bradshaw reports in the past 36 months, grants or contracts from NIH/National Institutes on Aging (NIA) 1RF1AG058852 04/15/2018 – 03/31/2023 Bradshaw, Parkinson's Disease Foundation PF-RCE-1948 07/01/2019 – 06/30/2023 Przedborski, NIH/NIA 5R01AG067581 05/15/2020 – 01/31/2025 Bradshaw/Elyaman, NIH/NIA 5U01AG061356 09/30/2018 – 08/31/2023 Bennett/De Jager, NIH/NIA 1R21AG073882 08/15/2021 – 07/31/2023 Bradshaw, NIH/NIA 5R01AG076018 09/30/2021 – 05/31/2026 Bradshaw/Elyaman/Vardarajan, IDSA CU21-3089 01/24/2022 – 12/24/2022 Bradshaw, CZI 2021-235054 07/01/2021 – 06/30/2022 Bradshaw/Jiang; patents 2020 Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He Compositions and Methods for Treating Neurodegenerative Disorders with NADH and/or PEITC US 63/071,032; 2021 Elizabeth Bradshaw, Wassim Elyaman Compositions and Methods for the Treatment of Alzheimer's Disease 88800730-000443.

Publisher Copyright:
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.


  • APOE
  • Alzheimer's disease
  • TREM2
  • amyloid beta
  • astrocytes
  • biomarkers
  • dementia
  • inflammation
  • microglia
  • neurodegeneration
  • neuroglia
  • neuroinflammation
  • tau

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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