Apolipoprotein e genotypes in AA and AL amyloidoses

Mark S. Kindy, Frederick C. de Beer, William R. Markesbery, Mordechai Pras, Ivona Aksentijevich, Dan Kastner, Robert Kyle, Alan Solomon, Patricia Woo

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Apolipoprotein E (apoE) is associated with senile plaques in Alzheimer's disease (AD), and present in amyloid deposits in a variety of systemic amyloidoses. Recently, studies have shown that apoE4 allelic frequency is increased in patients with sporadic and familial late-onset AD and that apoE4 may represent a susceptibility gene for late-onset AD. We addressed the issue of whether a similar association of apoE4 exists in a number of systemic amyloidoses. Tissue was obtained from control subjects, AD patients, familial Mediterranean fever (FMF) patients, amyloid A (AA) amyloid secondary to juvenile chronic arthritis (JCA), and amyloid of the light chain type (myeloma or AL). There was a strong correlation of the apoE4 allele with sporadic and late-onset AD, but no significant increase in apoE4 with other amyloidoses. These data suggest that whereas apoE4 may be a risk factor in AD, it is not in other amyloidoses. However, given the association of apoE with all these amyloidoses, the possibility cannot be excluded that this apolipoprotein could be involved in systemic amyloidoses on an isotype non-selective basis.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalAmyloid
Volume2
Issue number3
DOIs
StatePublished - 1995

Bibliographical note

Funding Information:
The authors would like to thank Amy King and John Cranfill for their technical assistance. In addition, the authors would like to thank Dr. Martha Skinner for providing AA and AL DNA samples and helpful discussion. This work was supported in part by grants from the United States Public Health Services AG-1298 1 (MSK) and CA 10056 (AS). Dr. Solomon is an American Cancer Society Clinical Research Professor.

Funding

The authors would like to thank Amy King and John Cranfill for their technical assistance. In addition, the authors would like to thank Dr. Martha Skinner for providing AA and AL DNA samples and helpful discussion. This work was supported in part by grants from the United States Public Health Services AG-1298 1 (MSK) and CA 10056 (AS). Dr. Solomon is an American Cancer Society Clinical Research Professor.

FundersFunder number
U.S. Public Health ServiceCA 10056, AG-1298 1

    Keywords

    • Amyloid
    • Apolipoprotein E
    • Genotype
    • Polymerase chain reaction

    ASJC Scopus subject areas

    • Internal Medicine

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