Apoptosis and tumor resistance conferred by Par-4

Yanming Zhao, Vivek M. Rangnekar

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential.

Original languageEnglish
Pages (from-to)1867-1874
Number of pages8
JournalCancer Biology and Therapy
Issue number12
StatePublished - Dec 2008

Bibliographical note

Funding Information:
This study was supported by NIH/NCI grants CA60872, CA105453, and CA84511 (to V.M.R.).


  • Apoptosis
  • Cancer-specific
  • Par-4

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research


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