Apoptosis and tumor resistance conferred by Par-4

Yanming Zhao; Vivek M. Rangnekar

doi:10.4161/cbt.7.12.6945

Apoptosis and tumor resistance conferred by Par-4

Yanming Zhao
, Vivek M. Rangnekar

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential.

Original language	English
Pages (from-to)	1867-1874
Number of pages	8
Journal	Cancer Biology and Therapy
Volume	7
Issue number	12
DOIs	https://doi.org/10.4161/cbt.7.12.6945
State	Published - Dec 2008

Bibliographical note

Funding Information:
This study was supported by NIH/NCI grants CA60872, CA105453, and CA84511 (to V.M.R.).

Funding

This study was supported by NIH/NCI grants CA60872, CA105453, and CA84511 (to V.M.R.).

Funders	Funder number
NCI/NIH	CA105453, CA60872
National Childhood Cancer Registry – National Cancer Institute	R01CA084511

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Cancer-specific
Par-4

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

Access to Document

10.4161/cbt.7.12.6945

Cite this

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title = "Apoptosis and tumor resistance conferred by Par-4",

abstract = "Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential.",

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note = "Funding Information: This study was supported by NIH/NCI grants CA60872, CA105453, and CA84511 (to V.M.R.).",

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T1 - Apoptosis and tumor resistance conferred by Par-4

AU - Zhao, Yanming

AU - Rangnekar, Vivek M.

N1 - Funding Information: This study was supported by NIH/NCI grants CA60872, CA105453, and CA84511 (to V.M.R.).

PY - 2008/12

Y1 - 2008/12

N2 - Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential.

AB - Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential.

KW - Apoptosis

KW - Cancer-specific

KW - Par-4

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UR - https://www.scopus.com/pages/publications/58149116505#tab=citedBy

U2 - 10.4161/cbt.7.12.6945

DO - 10.4161/cbt.7.12.6945

M3 - Review article

C2 - 18836307

AN - SCOPUS:58149116505

SN - 1538-4047

VL - 7

SP - 1867

EP - 1874

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 12

ER -

Apoptosis and tumor resistance conferred by Par-4

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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