Abstract
Prostate apoptosis response-4 (Par-4) is a pro-apoptotic protein identified by differential hybridization in a screen for genes upregulated when prostate cancer cells are induced to undergo apoptosis. This protein is conserved in vertebrates and is expressed in almost all cell-types. Par-4 induction is associated with apoptosis in diverse cell culture and in vivo models of apoptosis. Par-4 is essential for apoptosis and enforced expression of Par-4 sensitizes cells to p53-independent apoptosis. Par-4 protein can abrogate cell survival function conferred by protein kinase C-ζ, Bcl-2, or NF-κB. Par-4 is downmodulated in renal cell carcinomas and replenishment of Par-4 levels in primary renal cell carcinoma cultures sensitizes the cells to apoptosis by chemotherapeutic agents. Par-4 induces apoptosis in cancer, Alzheimer's disease, and developmental paradigms, and is likely to play a role in ischemia | reperfusion injury. Future studies are being directed toward exploring the translational aspects of Par-4 in the design of therapeutics for cancer, neurodegenerative diseases, and ischemia | reperfusion-induced cardiac injury.
| Original language | English |
|---|---|
| Pages (from-to) | 215-236 |
| Number of pages | 22 |
| Journal | Advances in Cell Aging and Gerontology |
| Volume | 5 |
| Issue number | C |
| DOIs | |
| State | Published - 2001 |
Bibliographical note
Funding Information:The studies described here from my laboratory were supported by NIH/NCI grant R01 CA60872, CaPCURE grant, and the Council for Tobacco Research. I thank the current and past members of my laboratory especially Guofang (Shirley) Qiu, Sumathi Krishnan, Aysegul Nalca, Seong-Su Han, Stephen Sells, Swati Joshi-Barve, Scott Crist, Suzanne Humphreys, Prakash Nair, David Wood, Jr., Neeraj Maddiwar, and Jason Cook; and collaborators Yang Shi, Karl Heinz Scheidtmann, Michael Weinstein, Mansoor Ahmed, Erwin Boghaert, Neil Williams, Mark Mattson, and Robert Strange for contributing to the studies described here. Elegant studies from the
Funding
The studies described here from my laboratory were supported by NIH/NCI grant R01 CA60872, CaPCURE grant, and the Council for Tobacco Research. I thank the current and past members of my laboratory especially Guofang (Shirley) Qiu, Sumathi Krishnan, Aysegul Nalca, Seong-Su Han, Stephen Sells, Swati Joshi-Barve, Scott Crist, Suzanne Humphreys, Prakash Nair, David Wood, Jr., Neeraj Maddiwar, and Jason Cook; and collaborators Yang Shi, Karl Heinz Scheidtmann, Michael Weinstein, Mansoor Ahmed, Erwin Boghaert, Neil Williams, Mark Mattson, and Robert Strange for contributing to the studies described here. Elegant studies from the
| Funders | Funder number |
|---|---|
| Council for Tobacco Research | |
| National Institutes of Health (NIH) | |
| National Childhood Cancer Registry – National Cancer Institute | R01 CA60872 |
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
