APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: Implications for Alzheimer's disease

Hafiz Mohmmad Abdul; Gary L. Wenk; McGann Gramling; Beatrice Hauss-Wegrzyniak; D. Allan Butterfield

doi:10.1016/j.neulet.2004.06.077

APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: Implications for Alzheimer's disease

Hafiz Mohmmad Abdul
, Gary L. Wenk
, McGann Gramling
, Beatrice Hauss-Wegrzyniak
, D. Allan Butterfield

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Epidemiological and biochemical studies strongly implicate a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). Mutation in the PS-1 and APP genes, which increases production of the highly amyloidogenic amyloid β-peptide (Aβ42), is the major cause of familial AD. The AD brain is under significant oxidative stress, including protein oxidation and lipid peroxidation. In the present study, protein oxidation and lipid peroxidation were compared in the brain homogenates from knock-in mice expressing mutant human PS-1 and APP in relation to the intake of dietary cholesterol. The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid peroxidation, independent of dietary cholesterol. These results are discussed with reference to proposed therapeutic strategies of AD.

Original language	English
Pages (from-to)	148-150
Number of pages	3
Journal	Neuroscience Letters
Volume	368
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2004.06.077
State	Published - Sep 23 2004

Bibliographical note

Funding Information:
This research was supported in part by NIH to D.A.B. [AG-10836; AG-05119] and G.L.W. [AG10546; Alzheimer’s Assoc., IIRG-01-2654]

Funding

This research was supported in part by NIH to D.A.B. [AG-10836; AG-05119] and G.L.W. [AG10546; Alzheimer’s Assoc., IIRG-01-2654]

Funders	Funder number
National Institutes of Health (NIH)	AG-05119, IIRG-01-2654, AG-10836
National Institute on Aging	R01AG010546

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease
Amyloid precursor protein
Aβ(1-42)
Cholesterol
Lipid peroxidation
Oxidative stress
Presenilin-1
Protein carbonyl

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2004.06.077

Cite this

@article{4428545582d24e809ea114f1f3b6103b,

title = "APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: Implications for Alzheimer's disease",

abstract = "Epidemiological and biochemical studies strongly implicate a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). Mutation in the PS-1 and APP genes, which increases production of the highly amyloidogenic amyloid β-peptide (Aβ42), is the major cause of familial AD. The AD brain is under significant oxidative stress, including protein oxidation and lipid peroxidation. In the present study, protein oxidation and lipid peroxidation were compared in the brain homogenates from knock-in mice expressing mutant human PS-1 and APP in relation to the intake of dietary cholesterol. The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid peroxidation, independent of dietary cholesterol. These results are discussed with reference to proposed therapeutic strategies of AD.",

keywords = "Alzheimer's disease, Amyloid precursor protein, Aβ(1-42), Cholesterol, Lipid peroxidation, Oxidative stress, Presenilin-1, Protein carbonyl",

author = "\{Mohmmad Abdul\}, Hafiz and Wenk, \{Gary L.\} and McGann Gramling and Beatrice Hauss-Wegrzyniak and Butterfield, \{D. Allan\}",

note = "Funding Information: This research was supported in part by NIH to D.A.B. [AG-10836; AG-05119] and G.L.W. [AG10546; Alzheimer{\textquoteright}s Assoc., IIRG-01-2654]",

year = "2004",

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doi = "10.1016/j.neulet.2004.06.077",

language = "English",

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T1 - APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol

T2 - Implications for Alzheimer's disease

AU - Mohmmad Abdul, Hafiz

AU - Wenk, Gary L.

AU - Gramling, McGann

AU - Hauss-Wegrzyniak, Beatrice

AU - Butterfield, D. Allan

N1 - Funding Information: This research was supported in part by NIH to D.A.B. [AG-10836; AG-05119] and G.L.W. [AG10546; Alzheimer’s Assoc., IIRG-01-2654]

PY - 2004/9/23

Y1 - 2004/9/23

N2 - Epidemiological and biochemical studies strongly implicate a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). Mutation in the PS-1 and APP genes, which increases production of the highly amyloidogenic amyloid β-peptide (Aβ42), is the major cause of familial AD. The AD brain is under significant oxidative stress, including protein oxidation and lipid peroxidation. In the present study, protein oxidation and lipid peroxidation were compared in the brain homogenates from knock-in mice expressing mutant human PS-1 and APP in relation to the intake of dietary cholesterol. The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid peroxidation, independent of dietary cholesterol. These results are discussed with reference to proposed therapeutic strategies of AD.

AB - Epidemiological and biochemical studies strongly implicate a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). Mutation in the PS-1 and APP genes, which increases production of the highly amyloidogenic amyloid β-peptide (Aβ42), is the major cause of familial AD. The AD brain is under significant oxidative stress, including protein oxidation and lipid peroxidation. In the present study, protein oxidation and lipid peroxidation were compared in the brain homogenates from knock-in mice expressing mutant human PS-1 and APP in relation to the intake of dietary cholesterol. The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid peroxidation, independent of dietary cholesterol. These results are discussed with reference to proposed therapeutic strategies of AD.

KW - Alzheimer's disease

KW - Amyloid precursor protein

KW - Aβ(1-42)

KW - Cholesterol

KW - Lipid peroxidation

KW - Oxidative stress

KW - Presenilin-1

KW - Protein carbonyl

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U2 - 10.1016/j.neulet.2004.06.077

DO - 10.1016/j.neulet.2004.06.077

M3 - Article

C2 - 15351438

AN - SCOPUS:4444304720

SN - 0304-3940

VL - 368

SP - 148

EP - 150

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: Implications for Alzheimer's disease

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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