TY - JOUR
T1 - Application of CD271+ human bone marrow-derived
T2 - Stem cells for ischaemic heart disease therapy
AU - Ghodsizad, Ali
AU - Farag, Mina
AU - Loebe, Matthias
AU - Lumsden, Eric
AU - Phiechaczek, Christoph
AU - Karck, Matthias
AU - Ruhparwar, Arjang
PY - 2011/6
Y1 - 2011/6
N2 - Cell transplantation for myocardial regeneration has been shown to have beneficial effects on cardiac function after myocardial infarction. Here, we discuss the application of CD 271+ bone marrow-derived stem cells (BMCs) as novel markers for the enrichment of mesenchymal somatic stem cells. Injection of BMCs into ischaemic myocardium during surgery has been shown to be both feasible and safe. This novel approach might hold promise as an alternative to medical management in patients with severe ischaemic heart failure who are ineligible for conventional revascularisation.
AB - Cell transplantation for myocardial regeneration has been shown to have beneficial effects on cardiac function after myocardial infarction. Here, we discuss the application of CD 271+ bone marrow-derived stem cells (BMCs) as novel markers for the enrichment of mesenchymal somatic stem cells. Injection of BMCs into ischaemic myocardium during surgery has been shown to be both feasible and safe. This novel approach might hold promise as an alternative to medical management in patients with severe ischaemic heart failure who are ineligible for conventional revascularisation.
KW - Bone marrow-derived stem cells
KW - Ischaemic heart disease
KW - Somatic stem cells
KW - Stem cell therapy
UR - http://www.scopus.com/inward/record.url?scp=84856112998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856112998&partnerID=8YFLogxK
U2 - 10.15420/ecr.2011.7.4.280
DO - 10.15420/ecr.2011.7.4.280
M3 - Article
AN - SCOPUS:84856112998
SN - 1758-3756
VL - 7
SP - 280
EP - 282
JO - European Cardiology Review
JF - European Cardiology Review
IS - 4
ER -
