Approaches to Study the Role of S100 Proteins in Calcium-Dependent Cellular Responses

Linda J. Van Eldik, Danna B. Zimmer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Calcium is necessary for the optimal growth and cellular functions of most living organisms. For example, Ca is involved in the processes of muscle contraction, stimulus-secretion coupling, bone formation, blood clotting, cell proliferation and motility, and fertilization. Many regulatory actions of Ca are mediated through Ca-binding proteins. Calcium-modulated proteins are a subclass of Ca-binding proteins that are thought to be the major signal transducers of Ca acting as a cellular second messenger. Most Ca-modulated proteins are not enzymes but are effector proteins capable of transducing a Ca signal into a biological response by their ability to bind Ca reversibly and modulate the activity of other proteins in a Ca-dependent manner. This review focuses on a set of Ca-modulated proteins, the S100 proteins, and their possible roles in mediating Ca-dependent cellular events.

Original languageEnglish
Pages (from-to)2028-2034
Number of pages7
JournalJournal of Dairy Science
Issue number8
StatePublished - 1988

Bibliographical note

Copyright 2017 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics


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