Arsenic-induced epigenetic changes in cancer development

Wesley N. Saintilnord; Yvonne Fondufe-Mittendorf

doi:10.1016/j.semcancer.2021.03.019

Arsenic-induced epigenetic changes in cancer development

Wesley N. Saintilnord, Yvonne Fondufe-Mittendorf

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to millions of people worldwide by increasing susceptibility to various cancers and non-cancer illnesses. Since arsenic is not a mutagen, the mechanism by which it causes changes in gene expression and disease pathogenesis is not clear. One possible mechanism is through generation of reactive oxygen species. Another equally important mechanism still very much in its infancy is epigenetic dysregulation. In this review, we discuss recent discoveries underlying arsenic-induced epigenetic changes in cancer development. Importantly, we highlight the proposed mechanisms targeted by arsenic to drive oncogenic gene expression.

Original language	English
Pages (from-to)	195-205
Number of pages	11
Journal	Seminars in Cancer Biology
Volume	76
DOIs	https://doi.org/10.1016/j.semcancer.2021.03.019
State	Published - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Funding

This work was supported by National Institute of Environmental Health Sciences (NIEHS) grants R01ES030233 and 1R01ES024478 (YNF-M).

Funders	Funder number
National Institute of Environmental Health Sciences (NIEHS)	R01ES024478, R01ES030233

Keywords

Alternative splicing
Carcinogen
DNA methylation
Epigenetics
Heavy metal
Inorganic arsenic
Transcription

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2021.03.019

Cite this

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KW - Inorganic arsenic

KW - Transcription

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Arsenic-induced epigenetic changes in cancer development

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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