Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction

Monique T. Fontes, David L. McDonagh, Barbara Phillips-Bute, Ian J. Welsby, Mihai V. Podgoreanu, Manuel L. Fontes, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Objective To determine the effect of arterial normobaric hyperoxia during cardiopulmonary bypass (CPB) on postoperative neurocognitive function. The authors hypothesized that arterial hyperoxia during CPB is associated with neurocognitive decline at 6 weeks after cardiac surgery. Design Retrospective study of patients undergoing cardiac surgery with CPB. Setting A university hospital. Participants One thousand eighteen patients undergoing coronary artery bypass graft (CABG) or CABG + valve surgery with CPB who previously had been enrolled in prospective cognitive trials. Interventions A battery of neurocognitive measures was administered at baseline and 6 weeks after surgery. Anesthetic and surgical care was managed as clinically indicated. Measurements and Main Results Arterial hyperoxia was assessed primarily as the area under the curve (AUC) for the duration that PaO2 exceeded 200 mmHg during CPB and secondarily as the mean PaO2 during bypass, as a PaO2 = 300 mmHg at any point and as AUC>150 mmHg. Cognitive change was assessed both as a continuous change score and a dichotomous deficit rate. Multivariate regression accounting for age, years of education, baseline cognition, date of surgery, baseline postintubation PaO2, duration of CPB, and percent change in hematocrit level from baseline to lowest level during CPB revealed no significant association between hyperoxia during CPB and postoperative neurocognitive function. Conclusions Arterial hyperoxia during CPB was not associated with neurocognitive decline after 6 weeks in cardiac surgical patients.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number3
StatePublished - Jun 2014

Bibliographical note

Funding Information:
Supported in part by grants #AG09663 (MFN), #HL54316 (MFN), #HL069081 (MFN), #HL096978 (JPM), #HL109971 (JPM), #HL108280 (JPM) and #M01-RR-30 (Duke Clinical Research Centers Program) from the National Institutes of Health; grants #9951185U (JPM), #9970128N (MFN) from the American Heart Association; and by the Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.


  • cardiac surgery
  • cardiopulmonary bypass
  • hyperoxia
  • neurocognitive

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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