TY - JOUR
T1 - Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis
AU - Burikhanov, Ravshan
AU - Sviripa, Vitaliy M.
AU - Hebbar, Nikhil
AU - Zhang, Wen
AU - Layton, W. John
AU - Hamza, Adel
AU - Zhan, Chang Guo
AU - Watt, David S.
AU - Liu, Chunming
AU - Rangnekar, Vivek M.
N1 - Publisher Copyright:
© 2014 Nature America, Inc. All rights reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - The tumor suppressor protein prostate apoptosis response-4 (Par-4), which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds vimentin, displaces Par-4 from vimentin for secretion and triggers the efficient paracrine apoptosis of diverse cancer cells. Thus, targeting vimentin with Par-4 secretagogues efficiently induces paracrine apoptosis of tumor cells.
AB - The tumor suppressor protein prostate apoptosis response-4 (Par-4), which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds vimentin, displaces Par-4 from vimentin for secretion and triggers the efficient paracrine apoptosis of diverse cancer cells. Thus, targeting vimentin with Par-4 secretagogues efficiently induces paracrine apoptosis of tumor cells.
UR - http://www.scopus.com/inward/record.url?scp=84939957908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939957908&partnerID=8YFLogxK
U2 - 10.1038/nchembio.1631
DO - 10.1038/nchembio.1631
M3 - Article
C2 - 25218743
AN - SCOPUS:84939957908
SN - 1552-4450
VL - 10
SP - 924
EP - 926
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 11
ER -
