Assessing interactions for fixed-dose drug combinations in subcutaneous tumor xenograft studies

Jianrong Wu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Drug combinations in preclinical tumor xenograft studies are often assessed using fixed doses. Assessing the joint action of drug combinations with fixed doses has not been well developed in the literature. Here, an interaction index is proposed for fixed-dose drug combinations in a subcutaneous tumor xenograft model. Furthermore, a bootstrap percentile interval of the interaction index is also developed. The joint action of two drugs can be assessed on the basis of confidence limits of the interaction index. Tumor xenograft data from actual two-drug combination studies are analyzed to illustrate the proposed method.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalPharmaceutical Statistics
Volume12
Issue number3
DOIs
StatePublished - May 2013

Keywords

  • bootstrap
  • confidence interval
  • drug-drug combination
  • interaction index
  • log10 cell kill
  • right censoring

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Assessing interactions for fixed-dose drug combinations in subcutaneous tumor xenograft studies'. Together they form a unique fingerprint.

Cite this