Abstract
Drug combinations in preclinical tumor xenograft studies are often assessed using fixed doses. Assessing the joint action of drug combinations with fixed doses has not been well developed in the literature. Here, an interaction index is proposed for fixed-dose drug combinations in a subcutaneous tumor xenograft model. Furthermore, a bootstrap percentile interval of the interaction index is also developed. The joint action of two drugs can be assessed on the basis of confidence limits of the interaction index. Tumor xenograft data from actual two-drug combination studies are analyzed to illustrate the proposed method.
Original language | English |
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Pages (from-to) | 115-119 |
Number of pages | 5 |
Journal | Pharmaceutical Statistics |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - May 2013 |
Keywords
- bootstrap
- confidence interval
- drug-drug combination
- interaction index
- log10 cell kill
- right censoring
ASJC Scopus subject areas
- Statistics and Probability
- Pharmacology
- Pharmacology (medical)