Abstract
Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.
| Original language | English |
|---|---|
| Pages (from-to) | 535-543 |
| Number of pages | 9 |
| Journal | Journal of Biopharmaceutical Statistics |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1 2012 |
Bibliographical note
Funding Information:The authors are thankful to a anonymous referee whose comments improved this article. This work was supported in part by National Cancer Institute (NCI) support grant CA21765, CA23099, by the ASSISI Foundation of Memphis, and by the American Lebanese Syrian Associated Charities (ALSAC).
Keywords
- Bootstrap
- Confidence interval
- Drug combination
- Regression
- Xenograft model
ASJC Scopus subject areas
- Statistics and Probability
- Pharmacology
- Pharmacology (medical)