Assessment of non-stationarity of activation core during ventricular fibrillation via time-frequency representations

A. Patwardhan, S. Moghe, K. Wang, F. Leonelli

Research output: Contribution to journalArticlepeer-review

Abstract

Recent reports from experimental and modeling studies of epicardial electrical activation during VF suggest that non-stationarity of the core of activation modulates the frequency of surface ECG through the Doppler phenomenon. Our objective in the present study was to use time-frequency analysis nalysis to localize the frequency of the dominant rhythm as it evolved during VF. Surface ECGs were recorded during 10 seconds of electrically induced ventricular fibrillation in 11 dogs. Short time Fourier Transforms (STFT) and pseudo Wigner distributions (SPWD) were used to generate the time-frequency surfaces. Shown is the peak frequency of the dominant rhythm during 8 seconds of VF from one trial. Peak frequency varied from its mean value of ≈ 9.2 to between ≈ 7.5 and 10.5 Hz, a change consistent with that predicted using the core velocity ratios reported in the literature. Our results suggest that the variance of the location of peak frequency may be used as an estimate of the degree of non-stationarity of core of activation during VF. (Figure Presented).

Original languageEnglish
Pages (from-to)A496
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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