Assessment of predictive models for characterizing the atomization process in a spray dryer's bi-fluid nozzle

Sadegh Poozesh; Nico Setiawan; Nelson K. Akafuah; Kozo Saito; Patrick J. Marsac

doi:10.1016/j.ces.2018.01.033

Assessment of predictive models for characterizing the atomization process in a spray dryer's bi-fluid nozzle

Sadegh Poozesh, Nico Setiawan, Nelson K. Akafuah, Kozo Saito, Patrick J. Marsac

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Spray drying as a commonly used process to produce amorphous solid dispersions of poorly water soluble active pharmaceutical ingredients (API) involves dissolution of the API and often a polymer, surfactant, and/or other functional excipient(s) into a volatile solvent. This feed solution is then pumped to an atomizing nozzle to produce droplets inside the drying chamber. The current paper aims to utilize non-scaled parameters to characterize the atomization process. A bi-fluid nozzle with two different designs commonly used in a lab-scale spray dryer was investigated under different operating conditions. The feed solutions were made of several excipients commonly used to produce amorphous solid dispersion composites. Atomization characterization is presented via both mean droplet size and size distribution. Various models are evaluated for predicting droplet mean diameter and span suitable for extrapolating atomization in the spray drying process. These approaches may be extended to other nozzles and across scales.

Original language	English
Pages (from-to)	42-51
Number of pages	10
Journal	Chemical Engineering Science
Volume	180
DOIs	https://doi.org/10.1016/j.ces.2018.01.033
State	Published - Apr 28 2018

Bibliographical note

Funding Information:
We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS“; with grant number of U01FD004275.

Publisher Copyright:
© 2018

Keywords

Amorphous solid dispersion
Breakup phenomena
Droplet size distribution
Non-dimensional parameters
Spray drying

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Industrial and Manufacturing Engineering

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10.1016/j.ces.2018.01.033

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abstract = "Spray drying as a commonly used process to produce amorphous solid dispersions of poorly water soluble active pharmaceutical ingredients (API) involves dissolution of the API and often a polymer, surfactant, and/or other functional excipient(s) into a volatile solvent. This feed solution is then pumped to an atomizing nozzle to produce droplets inside the drying chamber. The current paper aims to utilize non-scaled parameters to characterize the atomization process. A bi-fluid nozzle with two different designs commonly used in a lab-scale spray dryer was investigated under different operating conditions. The feed solutions were made of several excipients commonly used to produce amorphous solid dispersion composites. Atomization characterization is presented via both mean droplet size and size distribution. Various models are evaluated for predicting droplet mean diameter and span suitable for extrapolating atomization in the spray drying process. These approaches may be extended to other nozzles and across scales.",

keywords = "Amorphous solid dispersion, Breakup phenomena, Droplet size distribution, Non-dimensional parameters, Spray drying",

author = "Sadegh Poozesh and Nico Setiawan and Akafuah, {Nelson K.} and Kozo Saito and Marsac, {Patrick J.}",

note = "Funding Information: We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS“; with grant number of U01FD004275. Publisher Copyright: {\textcopyright} 2018",

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AU - Poozesh, Sadegh

AU - Setiawan, Nico

AU - Akafuah, Nelson K.

AU - Saito, Kozo

AU - Marsac, Patrick J.

N1 - Funding Information: We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS“; with grant number of U01FD004275. Publisher Copyright: © 2018

PY - 2018/4/28

Y1 - 2018/4/28

N2 - Spray drying as a commonly used process to produce amorphous solid dispersions of poorly water soluble active pharmaceutical ingredients (API) involves dissolution of the API and often a polymer, surfactant, and/or other functional excipient(s) into a volatile solvent. This feed solution is then pumped to an atomizing nozzle to produce droplets inside the drying chamber. The current paper aims to utilize non-scaled parameters to characterize the atomization process. A bi-fluid nozzle with two different designs commonly used in a lab-scale spray dryer was investigated under different operating conditions. The feed solutions were made of several excipients commonly used to produce amorphous solid dispersion composites. Atomization characterization is presented via both mean droplet size and size distribution. Various models are evaluated for predicting droplet mean diameter and span suitable for extrapolating atomization in the spray drying process. These approaches may be extended to other nozzles and across scales.

AB - Spray drying as a commonly used process to produce amorphous solid dispersions of poorly water soluble active pharmaceutical ingredients (API) involves dissolution of the API and often a polymer, surfactant, and/or other functional excipient(s) into a volatile solvent. This feed solution is then pumped to an atomizing nozzle to produce droplets inside the drying chamber. The current paper aims to utilize non-scaled parameters to characterize the atomization process. A bi-fluid nozzle with two different designs commonly used in a lab-scale spray dryer was investigated under different operating conditions. The feed solutions were made of several excipients commonly used to produce amorphous solid dispersion composites. Atomization characterization is presented via both mean droplet size and size distribution. Various models are evaluated for predicting droplet mean diameter and span suitable for extrapolating atomization in the spray drying process. These approaches may be extended to other nozzles and across scales.

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KW - Droplet size distribution

KW - Non-dimensional parameters

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Assessment of predictive models for characterizing the atomization process in a spray dryer's bi-fluid nozzle

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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