Association between air pollutants and cardiovascular disease mortality in Wuhan, China

Yisi Liu, Xi Chen, Shuqiong Huang, Liqiao Tian, Yuan'an Lu, Yan Mei, Meng Ren, Na Li, Li Liu, Hao Xiang

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


We examined the associations of daily mean concentrations of ambient air pollutants (particulate matter (PM10), sulfur dioxide (SO2), nitric oxide (NO2)) and daily cardiovascular diseases (CVD) mortality in Wuhan, China using a case-crossover design to analyze four years of data (2006–2009) collected from the Hubei Provincial Center for Disease Control and Prevention and the Wuhan Environmental Protection Bureau. From 2006 to 2009, daily average concentrations of PM10, SO2and NO2were 115.60 μg/m3, 53.21 μg/m3and 53.08 μg/m3, respectively. After adjusting for temperature and relative humidity, a 10 μg/m3increase in SO2and NO2over a 24-h period was associated with CVD mortality relative risk (R.R.) of 1.010 (95% CI: 1.000, 1.020) for SO2and 1.019 (95% CI: 1.005, 1.033) for NO2, but there was no significant association between increases in PM10 and mortality. Subgroup analysis on by gender showed a significant association of 1.026 (95% CI: 1.007, 1.045) between NO2and CVD among males, while no significant statistical effect was shown among females. Subgroup analysis by age showed that for those older than 65 years, every 10 μg/m3increase in NO2was associated with a 1.6% (95% CI: 0.1%, 3.1%) increase in CVD mortality. Subgroup analysis on different types of CVD showed that every 10 μg/m3increase in PM10and SO2were significantly associated with an approximately 1.012 (95% CI: 1.002, 1.022) and 1.021 (95% CI: 1.002, 1.040) increase, respectively, in ischemic heart disease (ICH) mortality. In conclusion, exposure to NO2is significantly associated with CVD mortality. Larger, multi-center studies in Chinese cities are being currently conducted to validate these findings.

Original languageEnglish
Pages (from-to)3506-3516
Number of pages11
JournalInternational Journal of Environmental Research and Public Health
Issue number4
StatePublished - Mar 25 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.


  • Cardiovascular disease
  • Mortality
  • NO
  • PM
  • SO

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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