Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study

Xiaoming Jia; Caroline Sun; Hirofumi Tanaka; Mahmoud Al Rifai; David Aguilar; Chiadi Ndumele; Elizabeth Selvin; Salim S. Virani; Ron C. Hoogeveen; Gerardo Heiss; Christie M. Ballantyne; Vijay Nambi

doi:10.1024/0301-1526/a000968

Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study

Xiaoming Jia, Caroline Sun, Hirofumi Tanaka, Mahmoud Al Rifai, David Aguilar, Chiadi Ndumele, Elizabeth Selvin, Salim S. Virani, Ron C. Hoogeveen, Gerardo Heiss, Christie M. Ballantyne, Vijay Nambi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.

Original language	English
Pages (from-to)	439-445
Number of pages	7
Journal	Vasa - European Journal of Vascular Medicine
Volume	50
Issue number	6
DOIs	https://doi.org/10.1024/0301-1526/a000968
State	Published - Nov 2021

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I).

Publisher Copyright:
© 2021 Hogrefe Verlag GmbH & Co. KG. All rights reserved.

Keywords

Galectin-3
aging
arterial stiffness

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1024/0301-1526/a000968

Cite this

Jia, X., Sun, C., Tanaka, H., Al Rifai, M., Aguilar, D., Ndumele, C., Selvin, E., Virani, S. S., Hoogeveen, R. C., Heiss, G., Ballantyne, C. M., & Nambi, V. (2021). Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study. Vasa - European Journal of Vascular Medicine, 50(6), 439-445. https://doi.org/10.1024/0301-1526/a000968

@article{25b3c670137f49faa8a8acc30353bcc4,

title = "Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study",

abstract = "Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.",

keywords = "Galectin-3, aging, arterial stiffness",

author = "Xiaoming Jia and Caroline Sun and Hirofumi Tanaka and {Al Rifai}, Mahmoud and David Aguilar and Chiadi Ndumele and Elizabeth Selvin and Virani, {Salim S.} and Hoogeveen, {Ron C.} and Gerardo Heiss and Ballantyne, {Christie M.} and Vijay Nambi",

note = "Funding Information: The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I). Publisher Copyright: {\textcopyright} 2021 Hogrefe Verlag GmbH & Co. KG. All rights reserved.",

year = "2021",

month = nov,

doi = "10.1024/0301-1526/a000968",

language = "English",

volume = "50",

pages = "439--445",

journal = "Vasa - European Journal of Vascular Medicine",

issn = "0301-1526",

publisher = "Hogrefe Publishing",

number = "6",

}

Jia, X, Sun, C, Tanaka, H, Al Rifai, M, Aguilar, D, Ndumele, C, Selvin, E, Virani, SS, Hoogeveen, RC, Heiss, G, Ballantyne, CM & Nambi, V 2021, 'Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study', Vasa - European Journal of Vascular Medicine, vol. 50, no. 6, pp. 439-445. https://doi.org/10.1024/0301-1526/a000968

TY - JOUR

T1 - Association between circulating Galectin-3 and arterial stiffness in older adults

T2 - Atherosclerosis Risk in Communities (ARIC) Study

AU - Jia, Xiaoming

AU - Sun, Caroline

AU - Tanaka, Hirofumi

AU - Al Rifai, Mahmoud

AU - Aguilar, David

AU - Ndumele, Chiadi

AU - Selvin, Elizabeth

AU - Virani, Salim S.

AU - Hoogeveen, Ron C.

AU - Heiss, Gerardo

AU - Ballantyne, Christie M.

AU - Nambi, Vijay

N1 - Funding Information: The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I). Publisher Copyright: © 2021 Hogrefe Verlag GmbH & Co. KG. All rights reserved.

PY - 2021/11

Y1 - 2021/11

N2 - Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.

AB - Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.

KW - Galectin-3

KW - aging

KW - arterial stiffness

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U2 - 10.1024/0301-1526/a000968

DO - 10.1024/0301-1526/a000968

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AN - SCOPUS:85112656783

SN - 0301-1526

VL - 50

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EP - 445

JO - Vasa - European Journal of Vascular Medicine

JF - Vasa - European Journal of Vascular Medicine

IS - 6

ER -

Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study

Abstract

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