Association between dietary intake and function in amyotrophic lateral sclerosis

Jeri W. Nieves; Chris Gennings; Pam Factor-Litvak; Jonathan Hupf; Jessica Singleton; Valerie Sharf; Björn Oskarsson; J. Americo M.Fernandes Filho; Eric J. Sorenson; Emanuele D'Amico; Ray Goetz; Hiroshi Mitsumoto; Jess Singleton; Christa Campanella Beck; David Merle; Tejal Shah; Meredith Pasmantier Kim; Yei Won Lee; Georgia Christodoulou; Kate Dalton; Jessica Kidd; Erin Gilbert; Mary Kilty; Daragh Heitzman; Wendy Rodriguez; Shari Hand; Michelle Washington; Brent Spears; Brandie Burson; Richard S. Bedlack; Karen Grace; Candace Boyette; Jonathan S. Katz; Robert G. Miller; Dallas Forshew; Joni Beemsterboer; Will Harris; Shelley McCoy; Thaïs Zayas-Bazan; Chow Saephanh; Richard J. Barohn; April L. McVey; Mazen M. Dimachkie; Mamatha Pasnoor; Yunxia Wang; Maureen Walsh; Laura Herbelin; Joann Miller; Kristy Anderson; Sherry Klingerman; Delana Weis; Nanette Joyce; Steffany Lim; Michelle Cregan; Edward J. Kasarskis; Kathie Vanderpool; Deborah Taylor; Samantha Thomas; Jason King; Robert Wells; Catherine Lomen-Hoerth; Jennifer Murphy; Y. Nhy Duong; Dennis Robins; Claudia Villerme; Yvonne D. Rollins; Steven P. Ringel; Dianna Quan; Elizabeth Whitethorn; Tahseen Mozaffar; Annabel K. Wang; Veronica Martin; Brian Minton; Patricia Tully; Denise Davis; Pariwat Thaisetthawatkul; Cindy Cowardin; Russell Herstein; Andrea J. Swenson; Decontee Jimmeh-Fletcher; Heena Olalde; Jeri Sieren; Sharon P. Nations; Jeffrey Elliott; Jaya Trivedi; Nina Gorham; Jeremy M. Shefner; Mary Lou Watson; Jennifer Moore; Katie Markis; Megan Grosso; Jinsy A. Andrews; Agnes Koczon-Jaremko; Janet Bowen

doi:10.1001/jamaneurol.2016.3401

Association between dietary intake and function in amyotrophic lateral sclerosis

Jeri W. Nieves, Chris Gennings, Pam Factor-Litvak, Jonathan Hupf, Jessica Singleton, Valerie Sharf, Björn Oskarsson, J. Americo M.Fernandes Filho, Eric J. Sorenson, Emanuele D'Amico, Ray Goetz, Hiroshi Mitsumoto, Jess Singleton, Christa Campanella Beck, David Merle, Tejal Shah, Meredith Pasmantier Kim, Yei Won Lee, Georgia Christodoulou, Kate DaltonJessica Kidd, Erin Gilbert, Mary Kilty, Daragh Heitzman, Wendy Rodriguez, Shari Hand, Michelle Washington, Brent Spears, Brandie Burson, Richard S. Bedlack, Karen Grace, Candace Boyette, Jonathan S. Katz, Robert G. Miller, Dallas Forshew, Joni Beemsterboer, Will Harris, Shelley McCoy, Thaïs Zayas-Bazan, Chow Saephanh, Richard J. Barohn, April L. McVey, Mazen M. Dimachkie, Mamatha Pasnoor, Yunxia Wang, Maureen Walsh, Laura Herbelin, Joann Miller, Kristy Anderson, Sherry Klingerman, Delana Weis, Nanette Joyce, Steffany Lim, Michelle Cregan, Edward J. Kasarskis, Kathie Vanderpool, Deborah Taylor, Samantha Thomas, Jason King, Robert Wells, Catherine Lomen-Hoerth, Jennifer Murphy, Y. Nhy Duong, Dennis Robins, Claudia Villerme, Yvonne D. Rollins, Steven P. Ringel, Dianna Quan, Elizabeth Whitethorn, Tahseen Mozaffar, Annabel K. Wang, Veronica Martin, Brian Minton, Patricia Tully, Denise Davis, Pariwat Thaisetthawatkul, Cindy Cowardin, Russell Herstein, Andrea J. Swenson, Decontee Jimmeh-Fletcher, Heena Olalde, Jeri Sieren, Sharon P. Nations, Jeffrey Elliott, Jaya Trivedi, Nina Gorham, Jeremy M. Shefner, Mary Lou Watson, Jennifer Moore, Katie Markis, Megan Grosso, Jinsy A. Andrews, Agnes Koczon-Jaremko, Janet Bowen

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

IMPORTANCE There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). OBJECTIVE To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less. EXPOSURES Nutrient intake, measured using a modified Block Food Frequency Questionnaire (FFQ). MAIN OUTCOMES AND MEASURES Amyotrophic lateral sclerosis function, measured using the ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function, measured using percentage of predicted forced vital capacity (FVC). RESULTS Baseline data were available on 302 patients with ALS (median age, 63.2 years [interquartile range, 55.5-68.0 years]; 178 men and 124 women). Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC. Empirically weighted indices using the weighted quantile sum regression method of "good" micronutrients and "good" food groups were positively associated with ALSFRS-R scores (β [SE], 2.7 [0.69] and 2.9 [0.9], respectively) and percentage FVC (β [SE], 12.1 [2.8] and 11.5 [3.4], respectively) (all P < .001). Positive and significant associations with ALSFRS-R scores (β [SE], 1.5 [0.61]; P = .02) and percentage FVC (β [SE], 5.2 [2.2]; P = .02) for selected vitamins were found in exploratory analyses. CONCLUSIONS AND RELEVANCE Antioxidants, carotenes, fruits, and vegetableswere associated with higher ALS function at baseline by regression of nutrient indices and weighted quantile sum regression analysis.We also demonstrated the usefulness of the weighted quantile sum regression method in the evaluation of diet. Those responsible for nutritional care of the patient with ALS should consider promoting fruit and vegetable intake since they are high in antioxidants and carotenes.

Original language	English
Pages (from-to)	1425-1432
Number of pages	8
Journal	JAMA Neurology
Volume	73
Issue number	12
DOIs	https://doi.org/10.1001/jamaneurol.2016.3401
State	Published - Dec 1 2016

Bibliographical note

Funding Information:
Grant R01ES016348 from the National Institute of Environmental Health Sciences, National Institutes of Health, funded the entire study and the Muscular Dystrophy Association funded an earlier study that was incorporated into the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress. Muscular Dystrophy Association Wings Over Wall Street, The Judith and Jean Pape Adams Charitable Foundation, and Ride for Life also supported part of the study

Funding

Grant R01ES016348 from the National Institute of Environmental Health Sciences, National Institutes of Health, funded the entire study and the Muscular Dystrophy Association funded an earlier study that was incorporated into the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress. Muscular Dystrophy Association Wings Over Wall Street, The Judith and Jean Pape Adams Charitable Foundation, and Ride for Life also supported part of the study

Funders	Funder number
National Institutes of Health (NIH)
National Institutes of Health/National Institute of Environmental Health Sciences	P30ES023515, R01ES016348
National Institutes of Health/National Institute of Environmental Health Sciences
Muscular Dystrophy Association

ASJC Scopus subject areas

Clinical Neurology

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10.1001/jamaneurol.2016.3401

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Nieves, J. W., Gennings, C., Factor-Litvak, P., Hupf, J., Singleton, J., Sharf, V., Oskarsson, B., Filho, J. A. M. F., Sorenson, E. J., D'Amico, E., Goetz, R., Mitsumoto, H., Singleton, J., Beck, C. C., Merle, D., Shah, T., Kim, M. P., Lee, Y. W., Christodoulou, G., ... Bowen, J. (2016). Association between dietary intake and function in amyotrophic lateral sclerosis. JAMA Neurology, 73(12), 1425-1432. https://doi.org/10.1001/jamaneurol.2016.3401

@article{86fa26b9a683492dbfcc13250a92b88a,

title = "Association between dietary intake and function in amyotrophic lateral sclerosis",

abstract = "IMPORTANCE There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). OBJECTIVE To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less. EXPOSURES Nutrient intake, measured using a modified Block Food Frequency Questionnaire (FFQ). MAIN OUTCOMES AND MEASURES Amyotrophic lateral sclerosis function, measured using the ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function, measured using percentage of predicted forced vital capacity (FVC). RESULTS Baseline data were available on 302 patients with ALS (median age, 63.2 years [interquartile range, 55.5-68.0 years]; 178 men and 124 women). Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC. Empirically weighted indices using the weighted quantile sum regression method of {"}good{"} micronutrients and {"}good{"} food groups were positively associated with ALSFRS-R scores (β [SE], 2.7 [0.69] and 2.9 [0.9], respectively) and percentage FVC (β [SE], 12.1 [2.8] and 11.5 [3.4], respectively) (all P < .001). Positive and significant associations with ALSFRS-R scores (β [SE], 1.5 [0.61]; P = .02) and percentage FVC (β [SE], 5.2 [2.2]; P = .02) for selected vitamins were found in exploratory analyses. CONCLUSIONS AND RELEVANCE Antioxidants, carotenes, fruits, and vegetableswere associated with higher ALS function at baseline by regression of nutrient indices and weighted quantile sum regression analysis.We also demonstrated the usefulness of the weighted quantile sum regression method in the evaluation of diet. Those responsible for nutritional care of the patient with ALS should consider promoting fruit and vegetable intake since they are high in antioxidants and carotenes.",

author = "Nieves, {Jeri W.} and Chris Gennings and Pam Factor-Litvak and Jonathan Hupf and Jessica Singleton and Valerie Sharf and Bj{\"o}rn Oskarsson and Filho, {J. Americo M.Fernandes} and Sorenson, {Eric J.} and Emanuele D'Amico and Ray Goetz and Hiroshi Mitsumoto and Jess Singleton and Beck, {Christa Campanella} and David Merle and Tejal Shah and Kim, {Meredith Pasmantier} and Lee, {Yei Won} and Georgia Christodoulou and Kate Dalton and Jessica Kidd and Erin Gilbert and Mary Kilty and Daragh Heitzman and Wendy Rodriguez and Shari Hand and Michelle Washington and Brent Spears and Brandie Burson and Bedlack, {Richard S.} and Karen Grace and Candace Boyette and Katz, {Jonathan S.} and Miller, {Robert G.} and Dallas Forshew and Joni Beemsterboer and Will Harris and Shelley McCoy and Tha{\"i}s Zayas-Bazan and Chow Saephanh and Barohn, {Richard J.} and McVey, {April L.} and Dimachkie, {Mazen M.} and Mamatha Pasnoor and Yunxia Wang and Maureen Walsh and Laura Herbelin and Joann Miller and Kristy Anderson and Sherry Klingerman and Delana Weis and Nanette Joyce and Steffany Lim and Michelle Cregan and Kasarskis, {Edward J.} and Kathie Vanderpool and Deborah Taylor and Samantha Thomas and Jason King and Robert Wells and Catherine Lomen-Hoerth and Jennifer Murphy and Duong, {Y. Nhy} and Dennis Robins and Claudia Villerme and Rollins, {Yvonne D.} and Ringel, {Steven P.} and Dianna Quan and Elizabeth Whitethorn and Tahseen Mozaffar and Wang, {Annabel K.} and Veronica Martin and Brian Minton and Patricia Tully and Denise Davis and Pariwat Thaisetthawatkul and Cindy Cowardin and Russell Herstein and Swenson, {Andrea J.} and Decontee Jimmeh-Fletcher and Heena Olalde and Jeri Sieren and Nations, {Sharon P.} and Jeffrey Elliott and Jaya Trivedi and Nina Gorham and Shefner, {Jeremy M.} and Watson, {Mary Lou} and Jennifer Moore and Katie Markis and Megan Grosso and Andrews, {Jinsy A.} and Agnes Koczon-Jaremko and Janet Bowen",

note = "Funding Information: Grant R01ES016348 from the National Institute of Environmental Health Sciences, National Institutes of Health, funded the entire study and the Muscular Dystrophy Association funded an earlier study that was incorporated into the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress. Muscular Dystrophy Association Wings Over Wall Street, The Judith and Jean Pape Adams Charitable Foundation, and Ride for Life also supported part of the study",

year = "2016",

month = dec,

day = "1",

doi = "10.1001/jamaneurol.2016.3401",

language = "English",

volume = "73",

pages = "1425--1432",

number = "12",

}

Nieves, JW, Gennings, C, Factor-Litvak, P, Hupf, J, Singleton, J, Sharf, V, Oskarsson, B, Filho, JAMF, Sorenson, EJ, D'Amico, E, Goetz, R, Mitsumoto, H, Singleton, J, Beck, CC, Merle, D, Shah, T, Kim, MP, Lee, YW, Christodoulou, G, Dalton, K, Kidd, J, Gilbert, E, Kilty, M, Heitzman, D, Rodriguez, W, Hand, S, Washington, M, Spears, B, Burson, B, Bedlack, RS, Grace, K, Boyette, C, Katz, JS, Miller, RG, Forshew, D, Beemsterboer, J, Harris, W, McCoy, S, Zayas-Bazan, T, Saephanh, C, Barohn, RJ, McVey, AL, Dimachkie, MM, Pasnoor, M, Wang, Y, Walsh, M, Herbelin, L, Miller, J, Anderson, K, Klingerman, S, Weis, D, Joyce, N, Lim, S, Cregan, M, Kasarskis, EJ, Vanderpool, K, Taylor, D, Thomas, S, King, J, Wells, R, Lomen-Hoerth, C, Murphy, J, Duong, YN, Robins, D, Villerme, C, Rollins, YD, Ringel, SP, Quan, D, Whitethorn, E, Mozaffar, T, Wang, AK, Martin, V, Minton, B, Tully, P, Davis, D, Thaisetthawatkul, P, Cowardin, C, Herstein, R, Swenson, AJ, Jimmeh-Fletcher, D, Olalde, H, Sieren, J, Nations, SP, Elliott, J, Trivedi, J, Gorham, N, Shefner, JM, Watson, ML, Moore, J, Markis, K, Grosso, M, Andrews, JA, Koczon-Jaremko, A & Bowen, J 2016, 'Association between dietary intake and function in amyotrophic lateral sclerosis', JAMA Neurology, vol. 73, no. 12, pp. 1425-1432. https://doi.org/10.1001/jamaneurol.2016.3401

TY - JOUR

T1 - Association between dietary intake and function in amyotrophic lateral sclerosis

AU - Nieves, Jeri W.

AU - Gennings, Chris

AU - Factor-Litvak, Pam

AU - Hupf, Jonathan

AU - Singleton, Jessica

AU - Sharf, Valerie

AU - Oskarsson, Björn

AU - Filho, J. Americo M.Fernandes

AU - Sorenson, Eric J.

AU - D'Amico, Emanuele

AU - Goetz, Ray

AU - Mitsumoto, Hiroshi

AU - Singleton, Jess

AU - Beck, Christa Campanella

AU - Merle, David

AU - Shah, Tejal

AU - Kim, Meredith Pasmantier

AU - Lee, Yei Won

AU - Christodoulou, Georgia

AU - Dalton, Kate

AU - Kidd, Jessica

AU - Gilbert, Erin

AU - Kilty, Mary

AU - Heitzman, Daragh

AU - Rodriguez, Wendy

AU - Hand, Shari

AU - Washington, Michelle

AU - Spears, Brent

AU - Burson, Brandie

AU - Bedlack, Richard S.

AU - Grace, Karen

AU - Boyette, Candace

AU - Katz, Jonathan S.

AU - Miller, Robert G.

AU - Forshew, Dallas

AU - Beemsterboer, Joni

AU - Harris, Will

AU - McCoy, Shelley

AU - Zayas-Bazan, Thaïs

AU - Saephanh, Chow

AU - Barohn, Richard J.

AU - McVey, April L.

AU - Dimachkie, Mazen M.

AU - Pasnoor, Mamatha

AU - Wang, Yunxia

AU - Walsh, Maureen

AU - Herbelin, Laura

AU - Miller, Joann

AU - Anderson, Kristy

AU - Klingerman, Sherry

AU - Weis, Delana

AU - Joyce, Nanette

AU - Lim, Steffany

AU - Cregan, Michelle

AU - Kasarskis, Edward J.

AU - Vanderpool, Kathie

AU - Taylor, Deborah

AU - Thomas, Samantha

AU - King, Jason

AU - Wells, Robert

AU - Lomen-Hoerth, Catherine

AU - Murphy, Jennifer

AU - Duong, Y. Nhy

AU - Robins, Dennis

AU - Villerme, Claudia

AU - Rollins, Yvonne D.

AU - Ringel, Steven P.

AU - Quan, Dianna

AU - Whitethorn, Elizabeth

AU - Mozaffar, Tahseen

AU - Wang, Annabel K.

AU - Martin, Veronica

AU - Minton, Brian

AU - Tully, Patricia

AU - Davis, Denise

AU - Thaisetthawatkul, Pariwat

AU - Cowardin, Cindy

AU - Herstein, Russell

AU - Swenson, Andrea J.

AU - Jimmeh-Fletcher, Decontee

AU - Olalde, Heena

AU - Sieren, Jeri

AU - Nations, Sharon P.

AU - Elliott, Jeffrey

AU - Trivedi, Jaya

AU - Gorham, Nina

AU - Shefner, Jeremy M.

AU - Watson, Mary Lou

AU - Moore, Jennifer

AU - Markis, Katie

AU - Grosso, Megan

AU - Andrews, Jinsy A.

AU - Koczon-Jaremko, Agnes

AU - Bowen, Janet

N1 - Funding Information: Grant R01ES016348 from the National Institute of Environmental Health Sciences, National Institutes of Health, funded the entire study and the Muscular Dystrophy Association funded an earlier study that was incorporated into the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress. Muscular Dystrophy Association Wings Over Wall Street, The Judith and Jean Pape Adams Charitable Foundation, and Ride for Life also supported part of the study

PY - 2016/12/1

Y1 - 2016/12/1

N2 - IMPORTANCE There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). OBJECTIVE To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less. EXPOSURES Nutrient intake, measured using a modified Block Food Frequency Questionnaire (FFQ). MAIN OUTCOMES AND MEASURES Amyotrophic lateral sclerosis function, measured using the ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function, measured using percentage of predicted forced vital capacity (FVC). RESULTS Baseline data were available on 302 patients with ALS (median age, 63.2 years [interquartile range, 55.5-68.0 years]; 178 men and 124 women). Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC. Empirically weighted indices using the weighted quantile sum regression method of "good" micronutrients and "good" food groups were positively associated with ALSFRS-R scores (β [SE], 2.7 [0.69] and 2.9 [0.9], respectively) and percentage FVC (β [SE], 12.1 [2.8] and 11.5 [3.4], respectively) (all P < .001). Positive and significant associations with ALSFRS-R scores (β [SE], 1.5 [0.61]; P = .02) and percentage FVC (β [SE], 5.2 [2.2]; P = .02) for selected vitamins were found in exploratory analyses. CONCLUSIONS AND RELEVANCE Antioxidants, carotenes, fruits, and vegetableswere associated with higher ALS function at baseline by regression of nutrient indices and weighted quantile sum regression analysis.We also demonstrated the usefulness of the weighted quantile sum regression method in the evaluation of diet. Those responsible for nutritional care of the patient with ALS should consider promoting fruit and vegetable intake since they are high in antioxidants and carotenes.

AB - IMPORTANCE There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). OBJECTIVE To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less. EXPOSURES Nutrient intake, measured using a modified Block Food Frequency Questionnaire (FFQ). MAIN OUTCOMES AND MEASURES Amyotrophic lateral sclerosis function, measured using the ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function, measured using percentage of predicted forced vital capacity (FVC). RESULTS Baseline data were available on 302 patients with ALS (median age, 63.2 years [interquartile range, 55.5-68.0 years]; 178 men and 124 women). Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC. Empirically weighted indices using the weighted quantile sum regression method of "good" micronutrients and "good" food groups were positively associated with ALSFRS-R scores (β [SE], 2.7 [0.69] and 2.9 [0.9], respectively) and percentage FVC (β [SE], 12.1 [2.8] and 11.5 [3.4], respectively) (all P < .001). Positive and significant associations with ALSFRS-R scores (β [SE], 1.5 [0.61]; P = .02) and percentage FVC (β [SE], 5.2 [2.2]; P = .02) for selected vitamins were found in exploratory analyses. CONCLUSIONS AND RELEVANCE Antioxidants, carotenes, fruits, and vegetableswere associated with higher ALS function at baseline by regression of nutrient indices and weighted quantile sum regression analysis.We also demonstrated the usefulness of the weighted quantile sum regression method in the evaluation of diet. Those responsible for nutritional care of the patient with ALS should consider promoting fruit and vegetable intake since they are high in antioxidants and carotenes.

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DO - 10.1001/jamaneurol.2016.3401

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JO - JAMA Neurology

JF - JAMA Neurology

IS - 12

ER -

Association between dietary intake and function in amyotrophic lateral sclerosis

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Bibliographical note

Funding

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