Association between impulsivity traits and body mass index at the observational and genetic epidemiology level

David Meyre; Sebat Mohamed; Joshua C. Gray; Jessica Weafer; James MacKillop; Harriet de Wit

doi:10.1038/s41598-019-53922-8

Association between impulsivity traits and body mass index at the observational and genetic epidemiology level

David Meyre, Sebat Mohamed, Joshua C. Gray, Jessica Weafer, James MacKillop, Harriet de Wit

Psychology

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3 Scopus citations

Abstract

We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georgia). We measured 14 impulsivity variables using three broad categories: impulsive choice, action and personality. Weight and height of participants were measured by research assistants. The single-nucleotide polymorphism (SNP) rs3751812 in the fat mass and obesity-associated (FTO) gene was genotyped using the Illumina PsychArray BeadChip platform. Within the three broad domains of impulsivity, 4 parameters (delay discounting of rewards area under the curve and average of k indexes, Conner’s continuous performance test, and negative urgency) were associated with BMI. The FTO rs3751812 minor allele T was associated with higher BMI. Of the 14 impulsivity variables, rs3751812 T was associated with more premeditation and perseverance, before and after adjusting for BMI. The association between FTO rs3751812 and BMI adjusted for premeditation remained significant, but disappeared after adjusting for perseverance and for both perseverance and premeditation traits. Our observational and genetic data indicate a complex pattern of association between impulsive behaviors and BMI in healthy young American-European adults.

Original language	English
Article number	17583
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-53922-8
State	Published - Dec 1 2019

Bibliographical note

Funding Information:
We wish to thank all the participants of the study. The opinions and assertions expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. This research was supported by the National Institute on Drug Abuse DA032015. David Meyre holds a Tier 2 Canada Research Chair in Genetics of Obesity. James MacKillop holds the Peter Boris Chair in Addictions Research. The funding agencies were not involved in the design, conduct, or publication of the study.

Publisher Copyright:
© 2019, The Author(s).

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10.1038/s41598-019-53922-8

Cite this

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abstract = "We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georgia). We measured 14 impulsivity variables using three broad categories: impulsive choice, action and personality. Weight and height of participants were measured by research assistants. The single-nucleotide polymorphism (SNP) rs3751812 in the fat mass and obesity-associated (FTO) gene was genotyped using the Illumina PsychArray BeadChip platform. Within the three broad domains of impulsivity, 4 parameters (delay discounting of rewards area under the curve and average of k indexes, Conner{\textquoteright}s continuous performance test, and negative urgency) were associated with BMI. The FTO rs3751812 minor allele T was associated with higher BMI. Of the 14 impulsivity variables, rs3751812 T was associated with more premeditation and perseverance, before and after adjusting for BMI. The association between FTO rs3751812 and BMI adjusted for premeditation remained significant, but disappeared after adjusting for perseverance and for both perseverance and premeditation traits. Our observational and genetic data indicate a complex pattern of association between impulsive behaviors and BMI in healthy young American-European adults.",

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Association between impulsivity traits and body mass index at the observational and genetic epidemiology level

Abstract

Bibliographical note

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UN SDGs

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