Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

Feifei Liu; Keith Dear; Lei Huang; Li Liu; Yun Shi; Shaofa Nie; Yisi Liu; Yuanan Lu; Hao Xiang

doi:10.1016/j.cancergen.2016.08.003

Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

Feifei Liu, Keith Dear, Lei Huang, Li Liu, Yun Shi, Shaofa Nie, Yisi Liu, Yuanan Lu, Hao Xiang

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02–1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27–1.76, p < 0.001; homozygote model: OR = 1.53, 95% CI: 1.28–1.83, p < 0.001; allele model: OR = 1.21, 95% CI: 1.11–1.31, p < 0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.

Original language	English
Pages (from-to)	388-394
Number of pages	7
Journal	Cancer genetics
Volume	209
Issue number	9
DOIs	https://doi.org/10.1016/j.cancergen.2016.08.003
State	Published - Sep 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Funding

This study was funded by National Natural Science Foundation of China (Grant No. 81402743 , Grant No. 81302491 and Grant No. 81172752 ); Hubei Province Health and Family Planning Scientific Research Project (Grant No. WJ2015Q023 ); The Fundamental Research Funds for the Central Universities (Grant No. 2042016kf0165 ); Doctoral Scientific Fund Project of the Ministry of Education of China (Grant No. 20130142120021 ).

Funders	Funder number
Hubei Province Health and Family Planning Scientific Research Project	WJ2015Q023
National Natural Science Foundation of China (NSFC)	81402743, 81302491, 81172752
National Natural Science Foundation of China (NSFC)
Ministry of Education of the People's Republic of China	20130142120021
Ministry of Education of the People's Republic of China
Fundamental Research Funds for the Central Universities	2042016kf0165
Fundamental Research Funds for the Central Universities

Keywords

Mir-27a
colorectal cancer
meta-analysis
polymorphism

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cancergen.2016.08.003

Cite this

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title = "Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis",

abstract = "Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95\% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95\% CI: 1.02–1.29, p = 0.02; recessive model: OR = 1.49, 95\% CI: 1.27–1.76, p < 0.001; homozygote model: OR = 1.53, 95\% CI: 1.28–1.83, p < 0.001; allele model: OR = 1.21, 95\% CI: 1.11–1.31, p < 0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.",

keywords = "Mir-27a, colorectal cancer, meta-analysis, polymorphism",

author = "Feifei Liu and Keith Dear and Lei Huang and Li Liu and Yun Shi and Shaofa Nie and Yisi Liu and Yuanan Lu and Hao Xiang",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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doi = "10.1016/j.cancergen.2016.08.003",

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T2 - A meta-analysis

AU - Liu, Feifei

AU - Dear, Keith

AU - Huang, Lei

AU - Liu, Li

AU - Shi, Yun

AU - Nie, Shaofa

AU - Liu, Yisi

AU - Lu, Yuanan

AU - Xiang, Hao

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N2 - Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02–1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27–1.76, p < 0.001; homozygote model: OR = 1.53, 95% CI: 1.28–1.83, p < 0.001; allele model: OR = 1.21, 95% CI: 1.11–1.31, p < 0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.

AB - Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02–1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27–1.76, p < 0.001; homozygote model: OR = 1.53, 95% CI: 1.28–1.83, p < 0.001; allele model: OR = 1.21, 95% CI: 1.11–1.31, p < 0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.

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Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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