Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia

Concepcion Vaquero Lorenzo, Enrique Baca-Garcia, Montserrat Diaz-Hernandez, Carlota Botillo-Martin, M. Mercedes Perez-Rodriguez, Carolina Fernandez-Ramos, M. Dolores Saiz-Gonzalez, Francisco J. Quintero-Gutierrez, Jeronimo Saiz-Ruiz, Jose Fernandez Piqueras, Jose Luis Gonzalez de Rivera, Jose de Leon

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).

Original languageEnglish
Pages (from-to)1136-1138
Number of pages3
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume30
Issue number6
DOIs
StatePublished - Aug 30 2006

Keywords

  • Schizophrenia
  • Serotonin 5-HT2A receptor
  • T102C polymorphism

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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