TY - JOUR
T1 - Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia
AU - Vaquero Lorenzo, Concepcion
AU - Baca-Garcia, Enrique
AU - Diaz-Hernandez, Montserrat
AU - Botillo-Martin, Carlota
AU - Perez-Rodriguez, M. Mercedes
AU - Fernandez-Ramos, Carolina
AU - Saiz-Gonzalez, M. Dolores
AU - Quintero-Gutierrez, Francisco J.
AU - Saiz-Ruiz, Jeronimo
AU - Fernandez Piqueras, Jose
AU - Gonzalez de Rivera, Jose Luis
AU - de Leon, Jose
PY - 2006/8/30
Y1 - 2006/8/30
N2 - Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).
AB - Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported. We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls. There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).
KW - Schizophrenia
KW - Serotonin 5-HT2A receptor
KW - T102C polymorphism
UR - http://www.scopus.com/inward/record.url?scp=33746986575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746986575&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2006.04.027
DO - 10.1016/j.pnpbp.2006.04.027
M3 - Article
C2 - 16762472
AN - SCOPUS:33746986575
SN - 0278-5846
VL - 30
SP - 1136
EP - 1138
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 6
ER -