Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort

Tomi Akinyemiju; Justin X. Moore; Maria Pisu; Michael Goodman; Virginia J. Howard; Monika Safford; Susan C. Gilchrist; Mary Cushman; Leann Long; Suzanne E. Judd

doi:10.18632/oncotarget.27108

Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort

Tomi Akinyemiju
, Justin X. Moore
, Maria Pisu
, Michael Goodman
, Virginia J. Howard
, Monika Safford
, Susan C. Gilchrist
, Mary Cushman
, Leann Long
, Suzanne E. Judd

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This study examines the association between inflammatory biomarkers and risk of cancer mortality by race. Data were obtained from 1,856 participants in the prospective REGARDS cohort who were cancer-free at baseline, and analyzed in relation to cancer mortality prospectively. Biomarkers were log-transformed and categorized into tertiles due to non-normal distributions, and Cox proportional hazard regression models were utilized to compute hazard ratios with 95% confidence intervals using robust sandwich methods. Individuals in the highest tertile of IL-6 had over a 12-fold increased risk of cancer mortality (HR: 12.97, 95% CI: 3.46-48.63); those in the highest tertile of IL-8 had over a 2-fold increased risk of cancer mortality (HR: 2.21, 95% CI: 0.86- 5.71), while those in the highest tertile of IL-10 had over a 3-fold increased risk of cancer mortality (HR: 3.06, 95% CI: 1.35-6.89). In race-stratified analysis, each unit increase in IL-6 was associated with increased risk of cancer mortality among African- Americans (HR: 3.88, 95% CI: 1.17-12.88) and Whites (5.25, 95% CI: 1.24-22.31). If replicated in larger, racially diverse prospective cohorts, these results suggest that cancer patients may benefit from clinical or lifestyle approaches to regulate systemic inflammation as a cancer prevention strategy.

Original language	English
Pages (from-to)	4857-4867
Number of pages	11
Journal	Oncotarget
Volume	10
Issue number	47
DOIs	https://doi.org/10.18632/oncotarget.27108
State	Published - Aug 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Impact Journals LLC. All rights reserved.

Funding

The REGARDS study was supported by cooperative agreement U01-NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Service. The authors thank the other investigators, the staff, and the participants of the REGARDS study for their valuable contributions. A full list of participating REGARDS investigators and institutions can be found at http://www. regardsstudy.org. This analysis was supported by award R01-NR012726 from the National Institute for Nursing Research, UL1-RR025777 from the National Center for Research Resources, K08HL096841 and R01HL080477 from the National Heart, Lung, and Blood Institute, and by grants from the Center for Clinical and Translational Science and the Lister Hill Center for Health Policy of the University of Alabama at Birmingham. Dr. Akinyemiju was supported by grant K01TW010271 from the NIH. Dr.Moore was supported by grants R25CA47888 and T32CA190194 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. Representatives of the funding agencies have been involved in the review of the manuscript but not directly involved in the collection, management, analysis or interpretation of the data.

Funders	Funder number
Department of Health and Human Service	R01-NR012726
Lister Hill Center for Health Policy of the University of Alabama at Birmingham	K01TW010271
National Institutes of Health (NIH)	R25CA47888
National Heart, Lung, and Blood Institute (NHLBI)
National Childhood Cancer Registry – National Cancer Institute	T32CA190194
National Institute of Health National Institute of Nursing Research
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council
National Center for Research Resources	R01HL080477, UL1RR025777, K08HL096841
Center for Clinical and Translational Science, University of Illinois at Chicago

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer mortality
Inflammatory biomarkers
Obesity
Racial disparities

ASJC Scopus subject areas

Oncology

Access to Document

10.18632/oncotarget.27108

Cite this

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title = "Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort",

abstract = "This study examines the association between inflammatory biomarkers and risk of cancer mortality by race. Data were obtained from 1,856 participants in the prospective REGARDS cohort who were cancer-free at baseline, and analyzed in relation to cancer mortality prospectively. Biomarkers were log-transformed and categorized into tertiles due to non-normal distributions, and Cox proportional hazard regression models were utilized to compute hazard ratios with 95\% confidence intervals using robust sandwich methods. Individuals in the highest tertile of IL-6 had over a 12-fold increased risk of cancer mortality (HR: 12.97, 95\% CI: 3.46-48.63); those in the highest tertile of IL-8 had over a 2-fold increased risk of cancer mortality (HR: 2.21, 95\% CI: 0.86- 5.71), while those in the highest tertile of IL-10 had over a 3-fold increased risk of cancer mortality (HR: 3.06, 95\% CI: 1.35-6.89). In race-stratified analysis, each unit increase in IL-6 was associated with increased risk of cancer mortality among African- Americans (HR: 3.88, 95\% CI: 1.17-12.88) and Whites (5.25, 95\% CI: 1.24-22.31). If replicated in larger, racially diverse prospective cohorts, these results suggest that cancer patients may benefit from clinical or lifestyle approaches to regulate systemic inflammation as a cancer prevention strategy.",

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AU - Safford, Monika

AU - Gilchrist, Susan C.

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Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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