Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

doi:10.1016/j.cgh.2022.09.026

Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

,

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Abstract

Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).

Original language	English
Pages (from-to)	1781-1791.e4
Journal	Clinical Gastroenterology and Hepatology
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.cgh.2022.09.026
State	Published - Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 AGA Institute

Funding

Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK108288 (to Mark D. Topazian, Santhi Swaroop Vege), U01DK108300 (to Walter G. Park), U01DK108306 (to Dhiraj Yadav), U01DK108314 (to Stephen J. Pandol), UO1DK108320 (to Christopher E. Forsmark), U01DK108323 (to Evan L. Fogel), U01DK108326 (to William E. Fisher), U01DK108327 (to Phil A. Hart, Darwin L. Conwell), UO1DK108322 (to Stephen K. Van Den Eeden), and U01DK108328 (to Liang Li, Minxing Chen, Yunlong Yang). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK108288 (to Mark D. Topazian, Santhi Swaroop Vege), U01DK108300 (to Walter G. Park), U01DK108306 (to Dhiraj Yadav), U01DK108314 (to Stephen J. Pandol), UO1DK108320 (to Christopher E. Forsmark), U01DK108323 (to Evan L. Fogel), U01DK108326 (to William E. Fisher), U01DK108327 (to Phil A. Hart, Darwin L. Conwell), UO1DK108322 (to Stephen K. Van Den Eeden), and U01DK108328 (to Liang Li, Minxing Chen, Yunlong Yang). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funders	Funder number
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108306, U01DK108328, U01DK108327, U01DK108323, U01DK108326, U01DK108314, UO1DK108320, UO1DK108322, U01DK108300, U01DK108288
National Institute of Diabetes and Digestive and Kidney Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anxiety
Depression
PROMIS
Pancreas
Pancreatitis
Sleep disturbance

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/j.cgh.2022.09.026

Cite this

@article{303bd4fd8ebd452aba38ce303b6a47e6,

title = "Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health",

abstract = "Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).",

keywords = "Anxiety, Depression, PROMIS, Pancreas, Pancreatitis, Sleep disturbance",

author = "Dhiraj Yadav and Askew, \{Robert L.\} and Tonya Palermo and Liang Li and Andersen, \{Dana K.\} and Minxing Chen and Fisher, \{William E.\} and Fogel, \{Evan L.\} and Forsmark, \{Christopher E.\} and Hart, \{Phil A.\} and Othman, \{Mohamed O.\} and Pandol, \{Stephen J.\} and Park, \{Walter G.\} and Topazian, \{Mark D.\} and \{Van Den Eeden\}, \{Stephen K.\} and Vege, \{Santhi Swaroop\} and Yunlong Yang and Jose Serrano and Conwell, \{Darwin L.\}",

note = "Publisher Copyright: {\textcopyright} 2023 AGA Institute",

year = "2023",

month = jul,

doi = "10.1016/j.cgh.2022.09.026",

language = "English",

volume = "21",

pages = "1781--1791.e4",

number = "7",

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TY - JOUR

T1 - Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

AU - Yadav, Dhiraj

AU - Askew, Robert L.

AU - Palermo, Tonya

AU - Li, Liang

AU - Andersen, Dana K.

AU - Chen, Minxing

AU - Fisher, William E.

AU - Fogel, Evan L.

AU - Forsmark, Christopher E.

AU - Hart, Phil A.

AU - Othman, Mohamed O.

AU - Pandol, Stephen J.

AU - Park, Walter G.

AU - Topazian, Mark D.

AU - Van Den Eeden, Stephen K.

AU - Vege, Santhi Swaroop

AU - Yang, Yunlong

AU - Serrano, Jose

AU - Conwell, Darwin L.

PY - 2023/7

Y1 - 2023/7

N2 - Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).

AB - Background and Aims: Pain is a cardinal symptom of chronic pancreatitis (CP). Using Patient-Reported Outcomes Measurement Information System (PROMIS) measures, we characterized physical and mental health and symptom profiles of a well-defined cohort of individuals with CP and compared them with control subjects. Among patients with CP, we also examined associations between pain (intensity, temporal nature) and PROMIS symptom profiles and the prevalence of clinically significant psychological comorbidities. Methods: We analyzed baseline data in 488 CP patients and 254 control subjects enrolled in PROCEED (Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies), an ongoing longitudinal cohort study. Participants completed the PROMIS-Global Health, which captures global physical and mental health, and the PROMIS-29 profile, which captures 7 symptom domains. Self-reported pain was categorized by severity (none, mild-moderate, severe) and temporal nature (none, intermittent, constant). Demographic and clinical data were obtained from the PROCEED database. Results: Pain was significantly associated with impairments in physical and mental health. Compared with participants with no pain, CP participants with severe pain (but not mild-moderate pain) had more decrements in each PROMIS domain in multivariable models (effect sizes, 2.54–7.03) and had a higher prevalence of clinically significant depression, anxiety, sleep disturbance, and physical disability (odds ratios, 2.11–4.74). Similar results were noted for constant pain (but not intermittent pain) for PROMIS domains (effect sizes, 4.08–10.37) and clinically significant depression, anxiety, sleep disturbance and physical disability (odds ratios, 2.80–5.38). Conclusions: Severe and constant pain are major drivers for poor psychological and physical health in CP. Systematic evaluation and management of psychiatric comorbidities and sleep disturbance should be incorporated into routine management of patients with CP. (ClinicalTrials.gov, Number: NCT03099850).

KW - Anxiety

KW - Depression

KW - PROMIS

KW - Pancreas

KW - Pancreatitis

KW - Sleep disturbance

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U2 - 10.1016/j.cgh.2022.09.026

DO - 10.1016/j.cgh.2022.09.026

M3 - Article

C2 - 36191836

AN - SCOPUS:85144450900

SN - 1542-3565

VL - 21

SP - 1781-1791.e4

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 7

ER -

Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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