Several epidemiologic studies have reported that body iron status and dietary iron intake are related to an increased risk of acute myocardial infarction (MI). However, it is completely unknown whether dietary iron reduction impacts the development of left ventricular (LV) remodeling after MI. Here, we investigate the effect of dietary iron restriction on the development of LV remodeling after MI in an experimental model. MI was induced in C57BL/6 J mice (9–11 weeks of age) by the permanent ligation of the left anterior descending coronary artery (LAD). At 2 weeks after LAD ligation, mice were randomly divided into two groups and were given a normal diet or an iron-restricted diet for 4 weeks. Sham operation without LAD ligation was also performed as controls. MI mice exhibited increased LV dilatation and impaired LV systolic function that was associated with cardiomyocyte hypertrophy and interstitial fibrosis in the remote area, as compared with the controls at 6 weeks after MI. In contrast, dietary iron restriction attenuated LV dilatation and impaired LV systolic function coupled to cardiomyocyte hypertrophy and interstitial fibrosis in the remote area. Importantly, cardiac expression of cellular iron transport proteins, transferrin receptor 1 and divalent metal transporter 1 was increased in the remote area of MI mice compared with the controls. Dietary iron restriction attenuated the development of LV remodeling after MI in mice. Cellular iron transport might play a role in the pathophysiological mechanism of LV remodeling after MI.
|Number of pages||8|
|Journal||Heart and Vessels|
|State||Published - Feb 1 2016|
Bibliographical noteFunding Information:
We gratefully thank Noriko Kumon, Sachi Ito, and Manami Hosokawa for their technical assistance. This study has been presented at American Heart Association 2013 Scientific Sessions (Dallas, TX, USA). This study was supported by a Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI Grant No. 25460919) and grants from Takeda Science Foundation and Hyogo Science and Technology Association (to Y. Naito).
© 2015, Springer Japan.
- Left ventricular remodeling
- Myocardial infarction
- Transferrin receptor 1
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine