TY - JOUR
T1 - Association of height with outcomes in patients with acute myocardial infarction receiving reperfusion therapy
AU - Mehta, Rajendra H.
AU - Califf, Robert M.
AU - Garg, Jyotsna
AU - Pieper, Karen S.
AU - Alexander, John H.
AU - Moliterno, David J.
AU - Van De Werf, Frans
AU - Ohman, E. Magnus
AU - White, Harvey D.
AU - Topol, Eric J.
AU - Granger, Christopher B.
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Data were evaluated for patients with acute ST-elevation myocardial infarction (n = 94,182) enrolled in 6 large clinical trials evaluating the efficacy of various reperfusion strategies. It was found that compared with the tallest quartile, incidences of in-hospital reinfarction, stroke, major bleeding, cardiogenic shock, heart failure, and death in the shortest group were 1.4, 1.7, 1.7, 1.8, 1.9, and 2.4 times greater, respectively. Although a strong inverse association of height was observed with unadjusted 30-day mortality (p <0.001), it was attenuated after adjustment for confounders, including weight, and appeared to be nonlinear, such that for height ≤165 cm, the odds ratio [OR] for a 10-cm increment in height was 1.115 (95% confidence interval [CI] 1.014 to 1.223) and for height >165 cm, the OR for a 10-cm increase in height was 0.962 (95% CI 0.896 to 1.033). These data indicate that height-related differences in 30-day mortality are explained in large part by height-related differences in patients' clinical characteristics.
AB - Data were evaluated for patients with acute ST-elevation myocardial infarction (n = 94,182) enrolled in 6 large clinical trials evaluating the efficacy of various reperfusion strategies. It was found that compared with the tallest quartile, incidences of in-hospital reinfarction, stroke, major bleeding, cardiogenic shock, heart failure, and death in the shortest group were 1.4, 1.7, 1.7, 1.8, 1.9, and 2.4 times greater, respectively. Although a strong inverse association of height was observed with unadjusted 30-day mortality (p <0.001), it was attenuated after adjustment for confounders, including weight, and appeared to be nonlinear, such that for height ≤165 cm, the odds ratio [OR] for a 10-cm increment in height was 1.115 (95% confidence interval [CI] 1.014 to 1.223) and for height >165 cm, the OR for a 10-cm increase in height was 0.962 (95% CI 0.896 to 1.033). These data indicate that height-related differences in 30-day mortality are explained in large part by height-related differences in patients' clinical characteristics.
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U2 - 10.1016/j.amjcard.2005.01.087
DO - 10.1016/j.amjcard.2005.01.087
M3 - Article
C2 - 15904648
AN - SCOPUS:21144451480
SN - 0002-9149
VL - 95
SP - 1371
EP - 1375
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 11
ER -