Association of improved cardiac function in donors with C34T mutation of the AMP deaminase 1 gene

A. H.Y. Yuen, M. H. Yacoub, E. J. Birks, K. K. Kalsi, P. H. Johnson, R. T. Smolenski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease. In this study, we examined the frequency of the mutation in the heart with good and poor cardiac function and in healthy controls. We found that there was no difference in the frequency of the mutation between the patients with heart failure and healthy controls. However, the frequency of the mutation in the healthy donor hearts was much higher when compared to healthy controls or donors with failing hearts.

Original languageEnglish
Pages (from-to)275-277
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume24
Issue number4
DOIs
StatePublished - 2005

Bibliographical note

Funding Information:
This study was supported by the Magdi Yacoub Institute and the British Heart Foundation. RTS is Senior Lecturer at the Department of Biochemistry, Medical University of Gdansk, Poland.

Keywords

  • AMP Deaminase
  • C34T Mutation
  • Heart Transplantation
  • Organ Donors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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