Association of manganese biomarker concentrations with blood pressure and kidney parameters among healthy adolescents: Nhanes 2013–2018

Maria D. Politis, Jacob C. Freedman, Erin N. Haynes, Alison P. Sanders

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Deficiency or excess exposure to manganese (Mn), an essential mineral, may have potentially adverse health effects. The kidneys are a major organ of Mn site-specific toxicity because of their unique role in filtration, metabolism, and excretion of xenobiotics. We hypothesized that Mn concentrations were associated with poorer blood pressure (BP) and kidney parameters such as estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), and albumin creatinine ratio (ACR). We conducted a cross-sectional analysis of 1931 healthy U.S. adolescents aged 12–19 years participating in National Health and Nutrition Examination Survey cycles 2013–2014, 2015–2016, and 2017–2018. Blood and urine Mn concentrations were measured using inductively coupled plasma mass spectrometry. Systolic and diastolic BP were calculated as the average of available readings. eGFR was calculated from serum creatinine using the Bedside Schwartz equation. We performed multiple linear regression, adjusting for age, sex, body mass index, race/ethnicity, and poverty income ratio. We observed null relationships between blood Mn concentrations with eGFR, ACR, BUN, and BP. In a subset of 691 participants, we observed that a 10-fold increase in urine Mn was associated with a 16.4 mL/min higher eGFR (95% Confidence Interval: 11.1, 21.7). These exploratory findings should be interpreted cautiously and warrant investigation in longitudinal studies.

Original languageEnglish
Article number846
Issue number10
StatePublished - Oct 2021

Bibliographical note

Funding Information:
Funding: This publication was partially supported by funding from NIH/NIEHS: R00ES027508, T32HL007824, ES02644601A1, ES016531, and P30ES026529. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Blood pressure
  • Blood urea nitrogen
  • Estimated glomerular filtration rate
  • Kidney parameters
  • Manganese

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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