Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States

Maxwell J. Rakutt; Ryan A. Mace; Caitlin E.W. Conley; Austin V. Stone; Stephen T. Duncan; Jonathan Greenberg; David C. Landy; Ana Maria Vranceanu; Cale A. Jacobs

doi:10.1177/08982643231153459

Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States

Maxwell J. Rakutt
, Ryan A. Mace
, Caitlin E.W. Conley
, Austin V. Stone
, Stephen T. Duncan
, Jonathan Greenberg
, David C. Landy
, Ana Maria Vranceanu
, Cale A. Jacobs

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objective: Given overlapping pathophysiology, this study sought to assess the association between osteoarthritis (OA), functional impairment, and cognitive impairment in the aging population. Methods: The National Health and Nutrition Examination Survey was used to identify participants >60 years of age. We analyzed multivariable associations of grouped participants that underwent cognitive function testing using linear and logistic regression, adjusting for sex, age, race, and ethnicity. Results: Of 2776 identified participants representing a population of 50,242,917, 40% did not report OA or functional limitations; 21% had OA but not functional limitations; 15% did not have OA but had functional limitations; 17% had OA and related functional limitations; and 7% had OA and non-arthritic functional limitations. OA was not independently associated with cognitive impairment. Contrarily, functional limitations were associated with cognitive impairment regardless of OA diagnosis. Discussion: Cognitive impairment is not associated with OA, but rather functional limitations, potentially guiding future intervention.

Original language	English
Pages (from-to)	643-650
Number of pages	8
Journal	Journal of Aging and Health
Volume	35
Issue number	9
DOIs	https://doi.org/10.1177/08982643231153459
State	Published - Oct 2023

Bibliographical note

Publisher Copyright:
© The Author(s) 2023.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Ana-Maria Vranceanu, PhD –Support for this study comes from National Center for Complementary and Integrative Health (R34AT010370 [MPIs Jacobs and Vranceanu] and R01AG075899 [PI Vranceanu]); Cale A. Jacobs, PhD–Support for this study comes from R34AT010370 (MPIs Jacobs and Vranceanu).

Funders	Funder number
National Center for Complementary and Integrative Health	R34AT010370, R01AG075899

Keywords

aging
cognitive impairment
dementia
functional limitations
osteoarthritis

ASJC Scopus subject areas

Health(social science)
Sociology and Political Science
Life-span and Life-course Studies

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10.1177/08982643231153459

Cite this

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title = "Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States",

abstract = "Objective: Given overlapping pathophysiology, this study sought to assess the association between osteoarthritis (OA), functional impairment, and cognitive impairment in the aging population. Methods: The National Health and Nutrition Examination Survey was used to identify participants >60 years of age. We analyzed multivariable associations of grouped participants that underwent cognitive function testing using linear and logistic regression, adjusting for sex, age, race, and ethnicity. Results: Of 2776 identified participants representing a population of 50,242,917, 40\% did not report OA or functional limitations; 21\% had OA but not functional limitations; 15\% did not have OA but had functional limitations; 17\% had OA and related functional limitations; and 7\% had OA and non-arthritic functional limitations. OA was not independently associated with cognitive impairment. Contrarily, functional limitations were associated with cognitive impairment regardless of OA diagnosis. Discussion: Cognitive impairment is not associated with OA, but rather functional limitations, potentially guiding future intervention.",

keywords = "aging, cognitive impairment, dementia, functional limitations, osteoarthritis",

author = "Rakutt, \{Maxwell J.\} and Mace, \{Ryan A.\} and Conley, \{Caitlin E.W.\} and Stone, \{Austin V.\} and Duncan, \{Stephen T.\} and Jonathan Greenberg and Landy, \{David C.\} and Vranceanu, \{Ana Maria\} and Jacobs, \{Cale A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2023",

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doi = "10.1177/08982643231153459",

language = "English",

volume = "35",

pages = "643--650",

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AU - Rakutt, Maxwell J.

AU - Mace, Ryan A.

AU - Conley, Caitlin E.W.

AU - Stone, Austin V.

AU - Duncan, Stephen T.

AU - Greenberg, Jonathan

AU - Landy, David C.

AU - Vranceanu, Ana Maria

AU - Jacobs, Cale A.

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2023/10

Y1 - 2023/10

N2 - Objective: Given overlapping pathophysiology, this study sought to assess the association between osteoarthritis (OA), functional impairment, and cognitive impairment in the aging population. Methods: The National Health and Nutrition Examination Survey was used to identify participants >60 years of age. We analyzed multivariable associations of grouped participants that underwent cognitive function testing using linear and logistic regression, adjusting for sex, age, race, and ethnicity. Results: Of 2776 identified participants representing a population of 50,242,917, 40% did not report OA or functional limitations; 21% had OA but not functional limitations; 15% did not have OA but had functional limitations; 17% had OA and related functional limitations; and 7% had OA and non-arthritic functional limitations. OA was not independently associated with cognitive impairment. Contrarily, functional limitations were associated with cognitive impairment regardless of OA diagnosis. Discussion: Cognitive impairment is not associated with OA, but rather functional limitations, potentially guiding future intervention.

AB - Objective: Given overlapping pathophysiology, this study sought to assess the association between osteoarthritis (OA), functional impairment, and cognitive impairment in the aging population. Methods: The National Health and Nutrition Examination Survey was used to identify participants >60 years of age. We analyzed multivariable associations of grouped participants that underwent cognitive function testing using linear and logistic regression, adjusting for sex, age, race, and ethnicity. Results: Of 2776 identified participants representing a population of 50,242,917, 40% did not report OA or functional limitations; 21% had OA but not functional limitations; 15% did not have OA but had functional limitations; 17% had OA and related functional limitations; and 7% had OA and non-arthritic functional limitations. OA was not independently associated with cognitive impairment. Contrarily, functional limitations were associated with cognitive impairment regardless of OA diagnosis. Discussion: Cognitive impairment is not associated with OA, but rather functional limitations, potentially guiding future intervention.

KW - aging

KW - cognitive impairment

KW - dementia

KW - functional limitations

KW - osteoarthritis

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Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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