Associations between regional brain physiology and trait impulsivity, motor inhibition, and impaired control over drinking

Jessica Weafer, Mario Dzemidzic, William Eiler, Brandon G. Oberlin, Yang Wang, David A. Kareken

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Trait impulsivity and poor inhibitory control are well-established risk factors for alcohol misuse, yet little is known about the associated neurobiological endophenotypes. Here we examined correlations among brain physiology and self-reported trait impulsive behavior, impaired control over drinking, and a behavioral measure of response inhibition. A sample of healthy drinkers (n=117) completed a pulsed arterial spin labeling (PASL) scan to quantify resting regional cerebral blood flow (rCBF), as well as measures of self-reported impulsivity (Eysenck I7 Impulsivity scale) and impaired control over drinking. A subset of subjects (n=40) performed a stop signal task during blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging to assess brain regions involved in response inhibition. Eysenck I7 scores were inversely related to blood flow in the right precentral gyrus. Significant BOLD activation during response inhibition occurred in an overlapping right frontal motor/premotor region. Moreover, impaired control over drinking was associated with reduced BOLD response in the same region. These findings suggest that impulsive personality and impaired control over drinking are associated with brain physiology in areas implicated in response inhibition. This is consistent with the idea that difficulty controlling behavior is due in part to impairment in motor restraint systems.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume233
Issue number2
DOIs
StatePublished - Aug 30 2015

Bibliographical note

Funding Information:
This research was supported by the National Institute on Alcohol Abuse and Alcoholism , The Indiana University Alcohol Research Center, P60 AA007611 ; R21 AA018020 (DAK) ; R01 AA017661 (DAK) ; and the National Institute on Drug Abuse Grant F32 DA033756 (JW) . NIAAA and NIDA had no involvement other than financial support.

Publisher Copyright:
© 2015 Elsevier Ireland Ltd.

Keywords

  • Alcohol
  • Cerebral blood flow
  • FMRI
  • Inhibitory control
  • Stop task

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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