Background: Continuous glucose monitoring (CGM) systems help reduce hypoglycemia in patients with type 1 diabetes (T1D). It remains unclear whether T1D patients with impaired awareness of hypoglycemia (IAH) continue to develop more hypoglycemia than those with normal hypoglycemia awareness (NA) despite CGM use. Materials and Methods: For this cross-sectional observational study, 99 T1D patients using real-time CGMs for ≥86% of time were recruited. Fifty and 49 patients were found to have NA and IAH (based on the Clarke questionnaire), respectively. Two-week CGM hypoglycemia data were collected. Results: IAH was associated with greater percentages of CGM values <70 and <54 mg/dL (P = 0.012, P = 0.004) compared to NA. Clarke scores correlated positively with the percentage of CGM values <70 and <54 mg/dL (P = 0.013, P = 0.004). IAH was also related to more events with glucose <70 and <54 mg/dL determined either with at ≥1 time point (P = 0.048, P = 0.003) or lasting ≥20 min (P = 0.016, P = 0.004). IAH patients presented with more day-time events with glucose <54 mg/dL (P = 0.015), nocturnal events with glucose levels <70 and <54 mg/dL (P = 0.009, P = 0.007) and longer day-time event duration with glucose levels <70 and <54 mg/dL (P < 0.001, P = 0.006), respectively. Conclusions: T1D patients with IAH continue to experience more hypoglycemia despite dedicated CGM use.
|Number of pages||7|
|Journal||Diabetes Technology and Therapeutics|
|State||Published - Nov 2020|
Bibliographical noteFunding Information:
The current study was supported by NIDDK/WUSM DRC 2P30DK020579, University of Utah Diabetes and Metabolism Research Center, NIDDK 5T32DK091317 and R01DK118082, and NCATS 1ULTR002538.
© 2020, Mary Ann Liebert, Inc., publishers.
- Continuous glucose monitoring
- Impaired awareness of hypoglycemia
- Type 1 diabetes
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Medical Laboratory Technology