Astilbin selectively induces dysfunction of liver-infiltrating cells - Novel protection from liver damage

Qiang Xu, Feihua Wu, Jingsong Cao, Ting Chen, Jieyun Jiang, Ikuo Saiki, Akihide Koda

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The present study aimed to examine the effect of astilbin, a flavanoid, on liver injury. When administered during the effector but not induction phase, astilbin significantly decreased the liver injury induced by delayed-type hypersensitivity to picryl chloride in mice. The pretreatment of nonparenchymal cells but not hepatocytes with astilbin in vitro caused a concentration- and time-dependent inhibition against the damage. Nonparenchymal cells isolated from astilbin-administered mice also showed a significant incompetence of hepatotoxicity, correlated with the inhibition of serum transaminase elevation. However, astilbin did not protect from CCl 4-induced liver damage. Furthermore, the flavanoid markedly promoted the apoptosis of nonparenchymal cells from liver-injured mice, whereas did not influence those from naive mice. These results suggest that astilbin provides improvement against liver injury through a selective dysfunction of liver-infiltrating cells rather than by protecting the hepatocyte membrane. Such characteristics will be of significance to pave a new way for treating immunologically related liver diseases and for developing new drugs. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - Jul 14 1999


  • Apoptosis
  • Astilbin
  • Delayed-type hypersensitivity
  • Hepatoprotection
  • Liver injury
  • Picryl chloride

ASJC Scopus subject areas

  • Pharmacology


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