Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease

Susan D. Kraner, Christopher M. Norris

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Calcineurin (CN) is a Ca2+/calmodulin-dependent protein phosphatase with high abundance in nervous tissue. Though enriched in neurons, CN can become strongly induced in subsets of activated astrocytes under different pathological conditions where it interacts extensively with the nuclear factor of activated T cells (NFATs). Recent work has shown that regions of small vessel damage are associated with the upregulation of a proteolized, highly active form of CN in nearby astrocytes, suggesting a link between the CN/NFAT pathway and chronic cerebrovascular disease. In this Mini Review article, we discuss CN/NFAT signaling properties in the context of vascular disease and use previous cell type-specific intervention studies in Alzheimer's disease and traumatic brain injury models as a framework to understand how astrocytic CN/NFATs may couple vascular pathology to neurodegeneration and cognitive loss.

Original languageEnglish
Article number287
JournalFrontiers in Aging Neuroscience
Volume10
Issue numberSEP
DOIs
StatePublished - Sep 21 2018

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grants AG027297, AG056998, AG051945 and a gift from the Hazel Embry Research Trust.

Publisher Copyright:
© 2007 - 2018 Frontiers Media S.A. All Rights Reserved.

Keywords

  • Alzheimer's disease
  • Ca2+
  • Excitotoxicity
  • Glia
  • Vascular contributions to cognitive impairment and dementia

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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