26 Scopus citations


Using a uniquely promiscuous engineered glycosyltransferase (GT) derived from the macrolide-inactivating GT OleD, a single-step asymmetric glucosylation of one 'arm' of the drug mitoxantrone was efficiently achieved in high stereo- and regiospecificity. The synthesis, structural elucidation, and anticancer activity of the corresponding mitoxantrone 4′-β-d-glucoside are described.

Original languageEnglish
Pages (from-to)2786-2788
Number of pages3
JournalOrganic Letters
Issue number10
StatePublished - May 20 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Asymmetric enzymatic glycosylation of mitoxantrone'. Together they form a unique fingerprint.

Cite this