Using a uniquely promiscuous engineered glycosyltransferase (GT) derived from the macrolide-inactivating GT OleD, a single-step asymmetric glucosylation of one 'arm' of the drug mitoxantrone was efficiently achieved in high stereo- and regiospecificity. The synthesis, structural elucidation, and anticancer activity of the corresponding mitoxantrone 4′-β-d-glucoside are described.
|Number of pages||3|
|State||Published - May 20 2011|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry