TY - JOUR
T1 - Asystole during treatment with amiodarone in a patient with persistent atrial tachycardia
AU - Kuo, Chien Suu
AU - Pratap Reddy, C.
AU - Paciotti, Mark V.
PY - 1985
Y1 - 1985
N2 - During treatment with amiodarone, digoxin and nadolol, asystole occurred repeatedly in a patient with chronic persistent automatic atrial tachycardia. Asystole did not occur after discontinuation of drug therapy, and rechallenge with amiodarone alone produced marked overdrive suppression of all pacemakers resulting in asystole. Amiodarone serum level was within therapeutic range. The possible electrophysiologic mechanisms by which amiodarone might suppress both normal and abnormal pacemakers are discussed. The occurrence of asystole at therapeutic serum concentration of amiodarone suggests that this drug should be used with caution.
AB - During treatment with amiodarone, digoxin and nadolol, asystole occurred repeatedly in a patient with chronic persistent automatic atrial tachycardia. Asystole did not occur after discontinuation of drug therapy, and rechallenge with amiodarone alone produced marked overdrive suppression of all pacemakers resulting in asystole. Amiodarone serum level was within therapeutic range. The possible electrophysiologic mechanisms by which amiodarone might suppress both normal and abnormal pacemakers are discussed. The occurrence of asystole at therapeutic serum concentration of amiodarone suggests that this drug should be used with caution.
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U2 - 10.1016/S0022-0736(85)80041-8
DO - 10.1016/S0022-0736(85)80041-8
M3 - Article
C2 - 3882871
AN - SCOPUS:0021990030
SN - 0022-0736
VL - 18
SP - 105
EP - 109
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 1
ER -