Atherosclerosis

Murray W. Huff, Alan Daugherty, Hong Lu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

Atherosclerotic diseases, such as myocardial infarction and stroke, are the major cause of morbidity and mortality in Western countries. Although atherosclerosis has been recognised as a multifactorial complex disease, dyslipidaemia is a major contributor. The link of dyslipidaemia to atherosclerosis initiation and progression is based on compelling evidence in human and experimental studies. It is also based on the ubiquitous presence of lipid-laden cells in atherosclerotic lesions. This chapter reviews the current advancements of research work in lipid and lipoprotein metabolism that have provided mechanistic insights into understanding atherosclerosis. We compile the recent literature showing the involvement of multiple cell types and molecules, including microRNAs, as potential mechanisms in the development of atherosclerosis. We also discuss the currently available and newly developed therapeutic approaches to improve dyslipidaemia that may benefit patients with atherosclerotic diseases.

Original languageEnglish
Title of host publicationBiochemistry of Lipids, Lipoproteins and Membranes
Subtitle of host publicationSixth Edition
Pages519-548
Number of pages30
DOIs
StatePublished - 2016

Keywords

  • Apolipoproteins
  • Atherosclerosis
  • Endothelial cells
  • Lipid
  • Lipoprotein
  • Lipoprotein receptors
  • Macrophages
  • MicroRNAs
  • Smooth muscle cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

Fingerprint

Dive into the research topics of 'Atherosclerosis'. Together they form a unique fingerprint.

Cite this