Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

Jiahuai Wang, Youwei Yan, Thomas P.J. Garrett, Jinhuan Liu, David W. Rodgers, Robert L. Garlick, George E. Tarr, Yasmin Husain, Ellis L. Reinherz, Stephen C. Harrison

Research output: Contribution to journalArticlepeer-review

536 Scopus citations

Abstract

The structure of an N-terminal fragment of CD4 has been determined to 2.4 Å resolution. It has two tightly abutting domains connected by a continuous β strand. Both have the immunoglobulin fold, but domain 2 has a truncated β barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocom-patibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalNature
Volume348
Issue number6300
DOIs
StatePublished - 1990

Bibliographical note

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • General

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