Atomoxetine enhances a short-term model of plasticity in humans

Donald J. Foster; David C. Good; Allison Fowlkes; Lumy Sawaki

doi:10.1016/j.apmr.2005.08.131

Atomoxetine enhances a short-term model of plasticity in humans

Donald J. Foster, David C. Good, Allison Fowlkes, Lumy Sawaki

Neurology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Objective: To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans. Design: Double-blind, randomized, and placebo-controlled crossover design. Setting: A laboratory in a hospital. Participants: A convenience sample of 10 healthy subjects. Intervention: An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. Main Outcome Measure: Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity. Results: Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ. Conclusions: These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.

Original language	English
Pages (from-to)	216-221
Number of pages	6
Journal	Archives of Physical Medicine and Rehabilitation
Volume	87
Issue number	2
DOIs	https://doi.org/10.1016/j.apmr.2005.08.131
State	Published - Feb 2006

Bibliographical note

Funding Information:
Supported by Wake Forest University (intramural grant no. BG 03-644). Drugs used in this study were provided by the Wake Forest University Baptist Medical Center pharmacy.

Funding

Supported by Wake Forest University (intramural grant no. BG 03-644). Drugs used in this study were provided by the Wake Forest University Baptist Medical Center pharmacy.

Funders	Funder number
Wake Forest University	BG 03-644

Keywords

Motor training
Neuronal plasticity
Norepinephrine
Rehabilitation

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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10.1016/j.apmr.2005.08.131

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title = "Atomoxetine enhances a short-term model of plasticity in humans",

abstract = "Objective: To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans. Design: Double-blind, randomized, and placebo-controlled crossover design. Setting: A laboratory in a hospital. Participants: A convenience sample of 10 healthy subjects. Intervention: An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. Main Outcome Measure: Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity. Results: Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ. Conclusions: These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.",

keywords = "Motor training, Neuronal plasticity, Norepinephrine, Rehabilitation",

author = "Foster, {Donald J.} and Good, {David C.} and Allison Fowlkes and Lumy Sawaki",

note = "Funding Information: Supported by Wake Forest University (intramural grant no. BG 03-644). Drugs used in this study were provided by the Wake Forest University Baptist Medical Center pharmacy. ",

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AU - Foster, Donald J.

AU - Good, David C.

AU - Fowlkes, Allison

AU - Sawaki, Lumy

N1 - Funding Information: Supported by Wake Forest University (intramural grant no. BG 03-644). Drugs used in this study were provided by the Wake Forest University Baptist Medical Center pharmacy.

PY - 2006/2

Y1 - 2006/2

N2 - Objective: To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans. Design: Double-blind, randomized, and placebo-controlled crossover design. Setting: A laboratory in a hospital. Participants: A convenience sample of 10 healthy subjects. Intervention: An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. Main Outcome Measure: Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity. Results: Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ. Conclusions: These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.

AB - Objective: To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans. Design: Double-blind, randomized, and placebo-controlled crossover design. Setting: A laboratory in a hospital. Participants: A convenience sample of 10 healthy subjects. Intervention: An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. Main Outcome Measure: Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity. Results: Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ. Conclusions: These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.

KW - Motor training

KW - Neuronal plasticity

KW - Norepinephrine

KW - Rehabilitation

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Atomoxetine enhances a short-term model of plasticity in humans

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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