Abstract
Attentional deficits are frequently seen in isolation as the presenting sign and symptom of neurodegenerative disease, manifest as mild cognitive impairment (MCI). Persistent ADHD in the geriatric population could well be misconstrued as MCI, leading to the incorrect assumption that such persons are succumbing to a neurodegenerative disease process. Alternatively, the molecular, neuroanatomic, or neurochemical abnormalities seen in ADHD may contribute to the development of de novo late life neurodegenerative disease. The present review examines the issue of causality vs confound regarding the association of ADHD with MCI, suggesting that both are tenable hypotheses.
| Original language | English |
|---|---|
| Pages (from-to) | 552-560 |
| Number of pages | 9 |
| Journal | Current Psychiatry Reports |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2012 |
Bibliographical note
Funding Information:Acknowledgments This study was supported by funding from National Institutes of Health/National Institute on Aging 1 P30 AG028383, National Institutes of Health LRP 1L30 AG032934, and the Sanders-Brown Foundation.
Funding Information:
Disclosure N. Ivanchak: none; K. Fletcher: none; G. A. Jicha: consultant to Eli Lilly and Pfizer, and grants from National Institute on Aging and National Institutes of Health.
Keywords
- ADHD
- Adult ADHD
- Alzheimer's disease
- Attention-deficit/hyperactivity disorder
- DLB
- Dementia with Lewy bodies
- FTD
- Frontotemporal dementia
- Genetics
- MCI
- Mild cognitive impairment
- Neuroimaging
- Neurotransmitter systems
- Older adults
- Parkinson's disease
- Pathogenesis
- Treatment
ASJC Scopus subject areas
- Psychiatry and Mental health
