TY - JOUR
T1 - Attenuation of hemorrhagic shock by the non-glucocorticoid 21-aminosteroid U74006F
AU - Hall, Edward D.
AU - Yonkers, Patricia A.
AU - McCall, John M.
PY - 1988/3/1
Y1 - 1988/3/1
N2 - The ability of the novel non-glucocorticoid 21-aminosteroid U74006F to protect against the development of hemorrhagic shock was examined in pentobarbital-anesthetized cats. The animals were hemon-haged to a mean arterial blood pressure (MAP) of 45-50 mm Hg where they were held for 2 h. At the end of the hemorrhage period, either vehicle, a 30 mg/kg dose of methylprednisolone sodium succinate, or a 10 mg/kg dose of U74006F was administered i.v. followed by reinfusion of the shed blood. In vehicle-treated animals, there was a progressive post-remfasion decline in the MAP over the subsequent 2 h. In the methylprednisolone-treated cats, the post-reinfusion decrease in the MAP was only slightly and not significantly better. In contrast, U74006F administration resulted in a significant mainte-nance of the MAP. These results suggest that U74006F may be efficacious for the attenuation of hemorrhagic shock and superior to conventional high dose glucocorticoid therapy in that context.
AB - The ability of the novel non-glucocorticoid 21-aminosteroid U74006F to protect against the development of hemorrhagic shock was examined in pentobarbital-anesthetized cats. The animals were hemon-haged to a mean arterial blood pressure (MAP) of 45-50 mm Hg where they were held for 2 h. At the end of the hemorrhage period, either vehicle, a 30 mg/kg dose of methylprednisolone sodium succinate, or a 10 mg/kg dose of U74006F was administered i.v. followed by reinfusion of the shed blood. In vehicle-treated animals, there was a progressive post-remfasion decline in the MAP over the subsequent 2 h. In the methylprednisolone-treated cats, the post-reinfusion decrease in the MAP was only slightly and not significantly better. In contrast, U74006F administration resulted in a significant mainte-nance of the MAP. These results suggest that U74006F may be efficacious for the attenuation of hemorrhagic shock and superior to conventional high dose glucocorticoid therapy in that context.
KW - 21-Aminosteroid
KW - Hemorrhagic shock
KW - Methylprednisolone
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U2 - 10.1016/0014-2999(88)90792-3
DO - 10.1016/0014-2999(88)90792-3
M3 - Article
C2 - 3366180
AN - SCOPUS:0023846372
SN - 0014-2999
VL - 147
SP - 299
EP - 303
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -