Attenuation of hemorrhagic shock by the non-glucocorticoid 21-aminosteroid U74006F

Edward D. Hall, Patricia A. Yonkers, John M. McCall

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The ability of the novel non-glucocorticoid 21-aminosteroid U74006F to protect against the development of hemorrhagic shock was examined in pentobarbital-anesthetized cats. The animals were hemon-haged to a mean arterial blood pressure (MAP) of 45-50 mm Hg where they were held for 2 h. At the end of the hemorrhage period, either vehicle, a 30 mg/kg dose of methylprednisolone sodium succinate, or a 10 mg/kg dose of U74006F was administered i.v. followed by reinfusion of the shed blood. In vehicle-treated animals, there was a progressive post-remfasion decline in the MAP over the subsequent 2 h. In the methylprednisolone-treated cats, the post-reinfusion decrease in the MAP was only slightly and not significantly better. In contrast, U74006F administration resulted in a significant mainte-nance of the MAP. These results suggest that U74006F may be efficacious for the attenuation of hemorrhagic shock and superior to conventional high dose glucocorticoid therapy in that context.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalEuropean Journal of Pharmacology
Volume147
Issue number2
DOIs
StatePublished - Mar 1 1988

Keywords

  • 21-Aminosteroid
  • Hemorrhagic shock
  • Methylprednisolone

ASJC Scopus subject areas

  • Pharmacology

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