Background: Patients' attitudes toward deprescribing are crucial to understand before developing interventions, but no such data exists in the medically underserved, health disparities population of rural Appalachian United States. Objective(s): Assess Appalachian women's openness to deprescribing medications and determine if polypharmacy influenced their attitudes toward deprescribing. Methods: Before and after a cognitive behavioral therapy intervention, middle-aged Appalachian women self-reported medication use and completed the revised Patients’ Attitudes Toward Deprescribing Questionnaire (rPATD). Responses were described, stratified by presence of polypharmacy. Results: 30 women completed the rPATD pre- and post-intervention (mean [SD] age 55.8 [6.6] years; 96.7% white). Those with polypharmacy (n = 16) had higher burden and involvement scores (median 2.8 vs 2.0, p = 0.01; 4.9 vs 4.6, p = 0.06), and lower appropriateness scores (3.4 vs 3.9, p = 0.04). Burden, concerns about stopping, and involvement factor scores were similar before and after the intervention (p = 0.08, 0.86, and 0.41 respectively). ≥90% of participants were satisfied with their current medications yet would be willing to stop one or more. Conclusions: Middle-aged women in rural Appalachian United States are open to deprescribing; polypharmacy is associated with lower belief in the appropriateness of medications. Larger studies are needed to inform future deprescribing interventions for this and other similarly disadvantaged populations.
|Number of pages||6|
|Journal||Research in Social and Administrative Pharmacy|
|State||Published - Oct 2020|
Bibliographical noteFunding Information:
Funding Sources: This work was supported by the Building Interdisciplinary Research Careers in Women's Health Program under the National Institute on Drug Abuse [ K12-DA035150 ], the National Institute on Aging [ R01-AG054130 ], the University of Kentucky Center for Clinical and Translational Sciences [ UL1-TROO1998 ], and pilot funding from the Igniting Research Collaborations Grant (University of Kentucky College of Pharmacy) . ER is supported by a Dementia Research Development fellowship from National Health and Medical Research Council-Australian Research Council .
ER reports a Dementia Research Development Fellowship from National Health and Medical Research Council-Australian Research Council.
MM, CB, and DM report grants from the Building Interdisciplinary Research Careers in Women's Health Program under the National Institute on Drug Abuse during the conduct of the study.
- Health disparities
- Medication appropriateness
ASJC Scopus subject areas
- Pharmaceutical Science