Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses

Liisa K. Selin; Meei Y. Lin; Kristy A. Kraemer; Drew M. Pardoll; Jonathan P. Schneck; Steven M. Varga; Paul A. Santolucito; Amelia K. Pinto; Raymond M. Welsh

doi:10.1016/S1074-7613(00)80147-8

Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses

Liisa K. Selin
, Meei Y. Lin
, Kristy A. Kraemer
, Drew M. Pardoll
, Jonathan P. Schneck
, Steven M. Varga
, Paul A. Santolucito
, Amelia K. Pinto
, Raymond M. Welsh

Research output: Contribution to journal › Article › peer-review

254 Scopus citations

Abstract

Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNγ assays, and D^b-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.

Original language	English
Pages (from-to)	733-742
Number of pages	10
Journal	Immunity
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S1074-7613(00)80147-8
State	Published - Dec 1999

Bibliographical note

Funding Information:
We thank Dr. M. B. A. Oldstone for LCMV variants and I. Stroynowski and G. Haemmerling for their technical assistance. This work was supported by National Institutes of Health research grants AR-35506 and AI-17672 to R. M. W.; Clinical Investigator Award AI01362 to L. K. S.; training grants AI-07272 and AI-07349 to L. K. S.; AI-29575, AI-45208, and NMSS (RG 2637A2/1) to J. S.; and CA86030–01 to D. P. The contents of this publication are solely the responsibility of the authors and do not represent the official view of the National Institute of Health.

Funding

We thank Dr. M. B. A. Oldstone for LCMV variants and I. Stroynowski and G. Haemmerling for their technical assistance. This work was supported by National Institutes of Health research grants AR-35506 and AI-17672 to R. M. W.; Clinical Investigator Award AI01362 to L. K. S.; training grants AI-07272 and AI-07349 to L. K. S.; AI-29575, AI-45208, and NMSS (RG 2637A2/1) to J. S.; and CA86030–01 to D. P. The contents of this publication are solely the responsibility of the authors and do not represent the official view of the National Institute of Health.

Funders	Funder number
NMSS	CA86030–01, RG 2637A2/1
National Institutes of Health (NIH)	AI01362, AI-45208, AI-07349, AI-07272, AI-17672, AI-29575
National Institute of Arthritis and Musculoskeletal and Skin Diseases	R01AR035506

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/S1074-7613(00)80147-8

Cite this

@article{86bbbbe3eacc420ab70e7566811a7bd1,

title = "Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses",

abstract = "Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNγ assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.",

author = "Selin, \{Liisa K.\} and Lin, \{Meei Y.\} and Kraemer, \{Kristy A.\} and Pardoll, \{Drew M.\} and Schneck, \{Jonathan P.\} and Varga, \{Steven M.\} and Santolucito, \{Paul A.\} and Pinto, \{Amelia K.\} and Welsh, \{Raymond M.\}",

note = "Funding Information: We thank Dr. M. B. A. Oldstone for LCMV variants and I. Stroynowski and G. Haemmerling for their technical assistance. This work was supported by National Institutes of Health research grants AR-35506 and AI-17672 to R. M. W.; Clinical Investigator Award AI01362 to L. K. S.; training grants AI-07272 and AI-07349 to L. K. S.; AI-29575, AI-45208, and NMSS (RG 2637A2/1) to J. S.; and CA86030–01 to D. P. The contents of this publication are solely the responsibility of the authors and do not represent the official view of the National Institute of Health.",

year = "1999",

month = dec,

doi = "10.1016/S1074-7613(00)80147-8",

language = "English",

volume = "11",

pages = "733--742",

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T2 - Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses

AU - Selin, Liisa K.

AU - Lin, Meei Y.

AU - Kraemer, Kristy A.

AU - Pardoll, Drew M.

AU - Schneck, Jonathan P.

AU - Varga, Steven M.

AU - Santolucito, Paul A.

AU - Pinto, Amelia K.

AU - Welsh, Raymond M.

N1 - Funding Information: We thank Dr. M. B. A. Oldstone for LCMV variants and I. Stroynowski and G. Haemmerling for their technical assistance. This work was supported by National Institutes of Health research grants AR-35506 and AI-17672 to R. M. W.; Clinical Investigator Award AI01362 to L. K. S.; training grants AI-07272 and AI-07349 to L. K. S.; AI-29575, AI-45208, and NMSS (RG 2637A2/1) to J. S.; and CA86030–01 to D. P. The contents of this publication are solely the responsibility of the authors and do not represent the official view of the National Institute of Health.

PY - 1999/12

Y1 - 1999/12

N2 - Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNγ assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.

AB - Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNγ assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.

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ER -

Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

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