TY - JOUR
T1 - Atypical conditions for quantitative recovery of acepromazine and chlorpromazine from plasma
AU - Ballard, Steve
AU - Tobin, Thomas
PY - 1981/5
Y1 - 1981/5
N2 - Recoveries of acepromazine and chiorpromazine from equine plasma were examined. Recoveries of both drugs- from plasma were poor under theoretically optima! conditions for basic drugs. When a wide range of extraction pH was examined, it was found that more complete recoveries of these drugs from plasma were achieved at pH 5-6. Use of /3 Hjchiorpromazine showed that the rate of migration of the drug from an aqueous to a nonpolar environment was much faster at pH 6.0 than at pH 9.2 from both plasma and buffer solutions. Times required for equilibration with agitation were 15 min at pH 6.0, 1 h at pH 9.2, and 2 h at pH 11.0. With these agitation times and pH values, recoveries were more than 95% complete.
AB - Recoveries of acepromazine and chiorpromazine from equine plasma were examined. Recoveries of both drugs- from plasma were poor under theoretically optima! conditions for basic drugs. When a wide range of extraction pH was examined, it was found that more complete recoveries of these drugs from plasma were achieved at pH 5-6. Use of /3 Hjchiorpromazine showed that the rate of migration of the drug from an aqueous to a nonpolar environment was much faster at pH 6.0 than at pH 9.2 from both plasma and buffer solutions. Times required for equilibration with agitation were 15 min at pH 6.0, 1 h at pH 9.2, and 2 h at pH 11.0. With these agitation times and pH values, recoveries were more than 95% complete.
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U2 - 10.1080/15287398109530016
DO - 10.1080/15287398109530016
M3 - Article
C2 - 7265306
AN - SCOPUS:0019424497
SN - 0098-4108
VL - 7
SP - 745
EP - 751
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
IS - 5
ER -