Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings

Merilyne C. Waldo; Ellen Cawthra; Lawrence E. Adler; Sherry Dubester; Mary Staunton; Herbert Nagamoto; Neil Baker; Alice Madison; Jack Simon; Ann Scherzinger; Carla Drebing; Greg Gerhardt; Robert Freedman

doi:10.1016/0920-9964(94)90067-1

Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings

Merilyne C. Waldo, Ellen Cawthra, Lawrence E. Adler, Sherry Dubester, Mary Staunton, Herbert Nagamoto, Neil Baker, Alice Madison, Jack Simon, Ann Scherzinger, Carla Drebing, Greg Gerhardt, Robert Freedman

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Schizophrenia may result from the concentrated action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increased catecholamine metabolism. Abnormal auditory sensory gating was found in all schizophrenics in the 11 families studied and in 8 of their 20 siblings. Compared with the schizophrenics, the clinically unaffected siblings with abnormal auditory gating had larger hippocampal volume. There was no similar difference for the siblings with normal gating. The siblings with abnormal auditory gating also had lower homovanillic acid levels than the other siblings. The data suggest that a familial neuronal deficit, identified by diminished sensory gating, may be a necessary, but not sufficient factor in the pathogenesis of schizophrenia. Individuals with this deficit are generally clinically unaffected, except for schizophrenics, who also have other abnormalities, such as diminished hippocampal volume and increased catecholamine metabolism.

Original language	English
Pages (from-to)	93-106
Number of pages	14
Journal	Schizophrenia Research
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0920-9964(94)90067-1
State	Published - May 1994

Bibliographical note

Funding Information:
This study was supported by funds from the Veteran’s Administration Medical Research Service, NARSAD, and USPHS Grants MH44212, MH00728, MH3832a1n, d RR00051.

Funding

This study was supported by funds from the Veteran’s Administration Medical Research Service, NARSAD, and USPHS Grants MH44212, MH00728, MH3832a1n, d RR00051.

Funders	Funder number
Veteran’s Administration Medical Research Service
National Institute of Mental Health	K01MH000728
U.S. Public Health Service	MH00728, MH44212, RR00051
National Alliance for Research on Schizophrenia and Depression

Keywords

(Schizophrenia)
Auditory evoked potential
Dopamine
Hippocampus
Homovanillic acid
Pathophysiology

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0920-9964(94)90067-1

Cite this

Waldo, M. C., Cawthra, E., Adler, L. E., Dubester, S., Staunton, M., Nagamoto, H., Baker, N., Madison, A., Simon, J., Scherzinger, A., Drebing, C., Gerhardt, G., & Freedman, R. (1994). Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings. Schizophrenia Research, 12(2), 93-106. https://doi.org/10.1016/0920-9964(94)90067-1

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abstract = "Schizophrenia may result from the concentrated action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increased catecholamine metabolism. Abnormal auditory sensory gating was found in all schizophrenics in the 11 families studied and in 8 of their 20 siblings. Compared with the schizophrenics, the clinically unaffected siblings with abnormal auditory gating had larger hippocampal volume. There was no similar difference for the siblings with normal gating. The siblings with abnormal auditory gating also had lower homovanillic acid levels than the other siblings. The data suggest that a familial neuronal deficit, identified by diminished sensory gating, may be a necessary, but not sufficient factor in the pathogenesis of schizophrenia. Individuals with this deficit are generally clinically unaffected, except for schizophrenics, who also have other abnormalities, such as diminished hippocampal volume and increased catecholamine metabolism.",

keywords = "(Schizophrenia), Auditory evoked potential, Dopamine, Hippocampus, Homovanillic acid, Pathophysiology",

author = "Waldo, \{Merilyne C.\} and Ellen Cawthra and Adler, \{Lawrence E.\} and Sherry Dubester and Mary Staunton and Herbert Nagamoto and Neil Baker and Alice Madison and Jack Simon and Ann Scherzinger and Carla Drebing and Greg Gerhardt and Robert Freedman",

note = "Funding Information: This study was supported by funds from the Veteran{\textquoteright}s Administration Medical Research Service, NARSAD, and USPHS Grants MH44212, MH00728, MH3832a1n, d RR00051.",

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Waldo, MC, Cawthra, E, Adler, LE, Dubester, S, Staunton, M, Nagamoto, H, Baker, N, Madison, A, Simon, J, Scherzinger, A, Drebing, C, Gerhardt, G & Freedman, R 1994, 'Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings', Schizophrenia Research, vol. 12, no. 2, pp. 93-106. https://doi.org/10.1016/0920-9964(94)90067-1

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AU - Waldo, Merilyne C.

AU - Cawthra, Ellen

AU - Adler, Lawrence E.

AU - Dubester, Sherry

AU - Staunton, Mary

AU - Nagamoto, Herbert

AU - Baker, Neil

AU - Madison, Alice

AU - Simon, Jack

AU - Scherzinger, Ann

AU - Drebing, Carla

AU - Gerhardt, Greg

AU - Freedman, Robert

N1 - Funding Information: This study was supported by funds from the Veteran’s Administration Medical Research Service, NARSAD, and USPHS Grants MH44212, MH00728, MH3832a1n, d RR00051.

PY - 1994/5

Y1 - 1994/5

N2 - Schizophrenia may result from the concentrated action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increased catecholamine metabolism. Abnormal auditory sensory gating was found in all schizophrenics in the 11 families studied and in 8 of their 20 siblings. Compared with the schizophrenics, the clinically unaffected siblings with abnormal auditory gating had larger hippocampal volume. There was no similar difference for the siblings with normal gating. The siblings with abnormal auditory gating also had lower homovanillic acid levels than the other siblings. The data suggest that a familial neuronal deficit, identified by diminished sensory gating, may be a necessary, but not sufficient factor in the pathogenesis of schizophrenia. Individuals with this deficit are generally clinically unaffected, except for schizophrenics, who also have other abnormalities, such as diminished hippocampal volume and increased catecholamine metabolism.

AB - Schizophrenia may result from the concentrated action of several pathophysiological factors. This pilot study compared the distribution of measurements of three such putative factors in 11 schizophrenics and their siblings: a neurophysiological deficit in auditory sensory gating, diminished hippocampal volume, and increased catecholamine metabolism. Abnormal auditory sensory gating was found in all schizophrenics in the 11 families studied and in 8 of their 20 siblings. Compared with the schizophrenics, the clinically unaffected siblings with abnormal auditory gating had larger hippocampal volume. There was no similar difference for the siblings with normal gating. The siblings with abnormal auditory gating also had lower homovanillic acid levels than the other siblings. The data suggest that a familial neuronal deficit, identified by diminished sensory gating, may be a necessary, but not sufficient factor in the pathogenesis of schizophrenia. Individuals with this deficit are generally clinically unaffected, except for schizophrenics, who also have other abnormalities, such as diminished hippocampal volume and increased catecholamine metabolism.

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KW - Hippocampus

KW - Homovanillic acid

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Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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