Autoantibodies profile in matching CSF and serum from AD and AMCI patients: Potential pathogenic role and link to oxidative damage

Fabio Di Domenico, Gilda Pupo, Esther Giraldo, Ana Lloret, Mari Carmen Badia, Maria Eugenia Schinina, Alessandra Giorgi, D. Allan Butterfield, Jose Vina, Marzia Perluigi

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Alzheimer disease (AD) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. Amyloid-s-peptide (As) forms senile plaques, which, together with hyperphosphorylated tau-based neurofibrillary tangles, are the hallmarks of AD neuropathology. Evidence support the involvement of immune system in AD progression and current concepts regarding its pathogenesis include the participation of inflammatory and autoimmune components in the neurodegenerative process. Pathologically, immune system components have been detected in the brain, cerebrospinal fluid (CSF) and in serum of AD subjects and their trend of variation correlates with disease progression. However, patients with AD present significantly lower levels of antibody immunoreactivity against As in serum and CSF than healthy controls suggesting that a depletion of such patrolling system is involved in the deposition of toxic aggregates in AD. Within this frame, incomplete and often controversial results are reported about CNS immune/ autoimmune responses during AD, and a better comprehension of such processes is needed. Our research will aim to shed light on the nature and potential role of autoantibodies in CSF and serum from AD and amnestic mild cognitive impairment (aMCI) patients compared to healthy subjects by using an immunoproteomics approach. Our method allows recognition of natural occurring antibodies by the identification of brain antigen targeted by human IgGs. Overall our data reveal that the alterations of autoantibodies profile both in CSF and serum follow disease staging and progression. However, we demonstrate a fair overlap between CSF and serum suggesting the existence of different immunogenic events. Interestingly, CSF autoantibodies recognized, among others, key players of energy metabolic pathway, including glycolysis and TCA cycle, found oxidatively modified in AD brain studies. These data suggest a potential casual sequence between oxidative damage at brain level, autoantibodies presence in CSF and reduced energy metabolism of AD patients.

Original languageEnglish
Pages (from-to)112-122
Number of pages11
JournalCurrent Alzheimer Research
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Bentham Science Publishers.

Keywords

  • Alzheimer disease
  • Autoantibodies
  • Autoimmunity
  • Cerebrospinal fluid
  • Immunoproteomics
  • Mild cognitive impairment

ASJC Scopus subject areas

  • General Medicine

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