Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier

Bela Kis; Lei Chen; Yoichi Ueta; David W. Busija

doi:10.1016/j.peptides.2005.07.009

Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier

Bela Kis, Lei Chen, Yoichi Ueta, David W. Busija

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

A unique feature of cerebral endothelial cells (CECs) is the formation of the blood-brain barrier (BBB), which contributes to the stability of the brain microenvironment. CECs are capable of producing several substances mediating endothelium-dependent vasorelaxation or vasoconstriction, regulating BBB permeability, and participating in the regulation of cell-cell interactions during inflammatory and immunological processes. The chemical nature of these mediators produced by CECs ranges from gaseous anorganic molecules (e.g. nitric oxide) through lipid mediators (e.g. prostaglandins) to peptides. Peptide mediators are a large and diverse family of bioactive molecules which can elicit multiple effects on cerebral endothelial functions. In this review, we summarize current knowledge of peptide mediators produced by CECs, such as adrenomedullin, angiotensin, endothelin and several others and their role in the regulation of BBB functions.

Original language	English
Pages (from-to)	211-222
Number of pages	12
Journal	Peptides
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.peptides.2005.07.009
State	Published - Jan 2006

Bibliographical note

Funding Information:
The authors gratefully thank Nancy Busija, for critical reading of the manuscript. The work in the authors’ labs was supported by Grant-in-Aid for JSPS Fellows (Nos. 98260, S-02167 and S-05146 for B.K.) and for Scientific Research on Priority Areas (No. 10218210 for Y.U.) and Exploratory Research (No. 14667020 for YU) from the Ministry of Education, Culture, Sports, Science and Technology, Japan and by grants from NIH (HL-30260, HL-66074, HL-65380, HL-77731, DK-62372 for D.W.B.) and AHA Bugher Foundation Award (0270114N for D.W.B.).

Keywords

Adrenomedullin
Angiotensin
Blood-brain barrier
Cytokine
Endothelin
Substance P

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2005.07.009

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abstract = "A unique feature of cerebral endothelial cells (CECs) is the formation of the blood-brain barrier (BBB), which contributes to the stability of the brain microenvironment. CECs are capable of producing several substances mediating endothelium-dependent vasorelaxation or vasoconstriction, regulating BBB permeability, and participating in the regulation of cell-cell interactions during inflammatory and immunological processes. The chemical nature of these mediators produced by CECs ranges from gaseous anorganic molecules (e.g. nitric oxide) through lipid mediators (e.g. prostaglandins) to peptides. Peptide mediators are a large and diverse family of bioactive molecules which can elicit multiple effects on cerebral endothelial functions. In this review, we summarize current knowledge of peptide mediators produced by CECs, such as adrenomedullin, angiotensin, endothelin and several others and their role in the regulation of BBB functions.",

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AU - Ueta, Yoichi

AU - Busija, David W.

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Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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