Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier

Bela Kis, Lei Chen, Yoichi Ueta, David W. Busija

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

A unique feature of cerebral endothelial cells (CECs) is the formation of the blood-brain barrier (BBB), which contributes to the stability of the brain microenvironment. CECs are capable of producing several substances mediating endothelium-dependent vasorelaxation or vasoconstriction, regulating BBB permeability, and participating in the regulation of cell-cell interactions during inflammatory and immunological processes. The chemical nature of these mediators produced by CECs ranges from gaseous anorganic molecules (e.g. nitric oxide) through lipid mediators (e.g. prostaglandins) to peptides. Peptide mediators are a large and diverse family of bioactive molecules which can elicit multiple effects on cerebral endothelial functions. In this review, we summarize current knowledge of peptide mediators produced by CECs, such as adrenomedullin, angiotensin, endothelin and several others and their role in the regulation of BBB functions.

Original languageEnglish
Pages (from-to)211-222
Number of pages12
JournalPeptides
Volume27
Issue number1
DOIs
StatePublished - Jan 2006

Bibliographical note

Funding Information:
The authors gratefully thank Nancy Busija, for critical reading of the manuscript. The work in the authors’ labs was supported by Grant-in-Aid for JSPS Fellows (Nos. 98260, S-02167 and S-05146 for B.K.) and for Scientific Research on Priority Areas (No. 10218210 for Y.U.) and Exploratory Research (No. 14667020 for YU) from the Ministry of Education, Culture, Sports, Science and Technology, Japan and by grants from NIH (HL-30260, HL-66074, HL-65380, HL-77731, DK-62372 for D.W.B.) and AHA Bugher Foundation Award (0270114N for D.W.B.).

Keywords

  • Adrenomedullin
  • Angiotensin
  • Blood-brain barrier
  • Cytokine
  • Endothelin
  • Substance P

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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