Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

doi:10.1016/j.cgh.2021.11.011

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Research output: Contribution to journal › Short survey › peer-review

15 Citations (SciVal)

Abstract

Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1.

Original language	English
Pages (from-to)	226-228.e1
Journal	Clinical Gastroenterology and Hepatology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.cgh.2021.11.011
State	Published - Jan 2023

Bibliographical note

Funding Information:
Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding Information:
Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Copyright © 2023. Published by Elsevier Inc.

Funding

Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funders	Funder number
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK108306, DK061451, UO1 DK126300, UO1 DK127367, DK077906, UO1 DK127377
National Institute of Diabetes and Digestive and Kidney Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Autoimmunity
Pilot Projects
Humans
Adult
Pancreatitis, Chronic/complications
Diabetes Mellitus
Insulin

ASJC Scopus subject areas

Hepatology
Gastroenterology

Access to Document

10.1016/j.cgh.2021.11.011

Cite this

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title = "Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study",

abstract = "Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25\%-75\% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from {"}bystander{"} injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1. ",

keywords = "Autoimmunity, Pilot Projects, Humans, Adult, Pancreatitis, Chronic/complications, Diabetes Mellitus, Insulin",

author = "Dhiraj Yadav and Whitcomb, \{David C.\} and Gong Tang and Adam Slivka and Melena Bellin and Samer AlKaade and Amann, \{Stephen T.\} and Anderson, \{Michelle A.\} and Peter Banks and Darwin Conwell and Brand, \{Randall E.\} and Cote, \{Gregory A.\} and Joseph Romagnuolo and Forsmark, \{Christopher E.\} and Timothy Gardner and Andres Gelrud and Nalini Guda and Michele Lewis and Thiruvengadam Muniraj and Sandhu, \{Bimaljit S.\} and Stuart Sherman and Vikesh Singh and Wilcox, \{C. Mel\}",

note = "Funding Information: Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Copyright {\textcopyright} 2023. Published by Elsevier Inc.",

year = "2023",

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doi = "10.1016/j.cgh.2021.11.011",

language = "English",

volume = "21",

pages = "226--228.e1",

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T1 - Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis

T2 - A Pilot Study

AU - Yadav, Dhiraj

AU - Whitcomb, David C.

AU - Tang, Gong

AU - Slivka, Adam

AU - Bellin, Melena

AU - AlKaade, Samer

AU - Amann, Stephen T.

AU - Anderson, Michelle A.

AU - Banks, Peter

AU - Conwell, Darwin

AU - Brand, Randall E.

AU - Cote, Gregory A.

AU - Romagnuolo, Joseph

AU - Forsmark, Christopher E.

AU - Gardner, Timothy

AU - Gelrud, Andres

AU - Guda, Nalini

AU - Lewis, Michele

AU - Muniraj, Thiruvengadam

AU - Sandhu, Bimaljit S.

AU - Sherman, Stuart

AU - Singh, Vikesh

AU - Wilcox, C. Mel

N1 - Funding Information: Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Funding Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers: DK061451 (DCW), DK077906 (DY), U01DK108306 (DY), UO1 DK127377 (DY), UO1 DK126300 (MB), and UO1 DK127367 (MB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Copyright © 2023. Published by Elsevier Inc.

PY - 2023/1

Y1 - 2023/1

N2 - Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1.

AB - Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation. 1.

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KW - Pilot Projects

KW - Humans

KW - Adult

KW - Pancreatitis, Chronic/complications

KW - Diabetes Mellitus

KW - Insulin

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U2 - 10.1016/j.cgh.2021.11.011

DO - 10.1016/j.cgh.2021.11.011

M3 - Short survey

C2 - 34793964

AN - SCOPUS:85121720316

SN - 1542-3565

VL - 21

SP - 226-228.e1

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 1

ER -

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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