Autophagy in Apicomplexa: A life sustaining death mechanism?

Anthony P. Sinai; Paul D. Roepe

doi:10.1016/j.pt.2012.06.006

Autophagy in Apicomplexa: A life sustaining death mechanism?

Anthony P. Sinai
, Paul D. Roepe

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Programmed cell death (PCD) pathways remain understudied in parasitic protozoa in spite of the fact that they provide potential targets for the development of new therapy. The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidence also points to autophagy as a mediator of death in certain physiological contexts. Bioinformatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa possess the capacity for PCD including a primordial form of apoptosis. Recent work in . Toxoplasma and emerging data from . Plasmodium suggest that autophagy-related processes may serve as an additional death promoting pathway in Apicomplexa. Detailed mechanistic studies into the molecular basis for PCD in parasitic protozoa represent a fertile area for investigation and drug development.

Original language	English
Pages (from-to)	358-364
Number of pages	7
Journal	Trends in Parasitology
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.pt.2012.06.006
State	Published - Sep 2012

Bibliographical note

Funding Information:
Work in the Roepe laboratory reported here was supported by the National Institutes of Health (NIH) (RO1AI056312 and RO1 AI045957). Work in the Sinai laboratory reported here was supported by NIH (RO1AI049367). We thank Ms Becca Eller and Mr David Gaviria for preparing Figures 1 and 2 , respectively, and for helpful discussions. We also thank Drs Peter Bradley and John Boothroyd for the mouse anti-F1β and rabbit anti-SAG1 antibodies, respectively.

Funding

Work in the Roepe laboratory reported here was supported by the National Institutes of Health (NIH) (RO1AI056312 and RO1 AI045957). Work in the Sinai laboratory reported here was supported by NIH (RO1AI049367). We thank Ms Becca Eller and Mr David Gaviria for preparing Figures 1 and 2 , respectively, and for helpful discussions. We also thank Drs Peter Bradley and John Boothroyd for the mouse anti-F1β and rabbit anti-SAG1 antibodies, respectively.

Funders

Funder number

National Institutes of Health (NIH)

RO1 AI045957, RO1AI056312

National Institute of Allergy and Infectious F32-AI286447 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI168214 Jason W. Rosch Diseases National Institute of Allergy and Infectious P30 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R00-AI166116 Christopher D. Radka Diseases National Institute of Allergy and Infectious T32-AI106700 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI192221 Jason W. Rosch Diseases National Inst...

R01AI049367

Keywords

Apicomplexa
Autophagy
Plasmodium
Programmed cell death (PCD)
Toxoplasma

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.pt.2012.06.006

Cite this

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title = "Autophagy in Apicomplexa: A life sustaining death mechanism?",

abstract = "Programmed cell death (PCD) pathways remain understudied in parasitic protozoa in spite of the fact that they provide potential targets for the development of new therapy. The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidence also points to autophagy as a mediator of death in certain physiological contexts. Bioinformatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa possess the capacity for PCD including a primordial form of apoptosis. Recent work in . Toxoplasma and emerging data from . Plasmodium suggest that autophagy-related processes may serve as an additional death promoting pathway in Apicomplexa. Detailed mechanistic studies into the molecular basis for PCD in parasitic protozoa represent a fertile area for investigation and drug development.",

keywords = "Apicomplexa, Autophagy, Plasmodium, Programmed cell death (PCD), Toxoplasma",

author = "Sinai, \{Anthony P.\} and Roepe, \{Paul D.\}",

note = "Funding Information: Work in the Roepe laboratory reported here was supported by the National Institutes of Health (NIH) (RO1AI056312 and RO1 AI045957). Work in the Sinai laboratory reported here was supported by NIH (RO1AI049367). We thank Ms Becca Eller and Mr David Gaviria for preparing Figures 1 and 2 , respectively, and for helpful discussions. We also thank Drs Peter Bradley and John Boothroyd for the mouse anti-F1β and rabbit anti-SAG1 antibodies, respectively.",

year = "2012",

month = sep,

doi = "10.1016/j.pt.2012.06.006",

language = "English",

volume = "28",

pages = "358--364",

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T2 - A life sustaining death mechanism?

AU - Sinai, Anthony P.

AU - Roepe, Paul D.

N1 - Funding Information: Work in the Roepe laboratory reported here was supported by the National Institutes of Health (NIH) (RO1AI056312 and RO1 AI045957). Work in the Sinai laboratory reported here was supported by NIH (RO1AI049367). We thank Ms Becca Eller and Mr David Gaviria for preparing Figures 1 and 2 , respectively, and for helpful discussions. We also thank Drs Peter Bradley and John Boothroyd for the mouse anti-F1β and rabbit anti-SAG1 antibodies, respectively.

PY - 2012/9

Y1 - 2012/9

N2 - Programmed cell death (PCD) pathways remain understudied in parasitic protozoa in spite of the fact that they provide potential targets for the development of new therapy. The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidence also points to autophagy as a mediator of death in certain physiological contexts. Bioinformatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa possess the capacity for PCD including a primordial form of apoptosis. Recent work in . Toxoplasma and emerging data from . Plasmodium suggest that autophagy-related processes may serve as an additional death promoting pathway in Apicomplexa. Detailed mechanistic studies into the molecular basis for PCD in parasitic protozoa represent a fertile area for investigation and drug development.

AB - Programmed cell death (PCD) pathways remain understudied in parasitic protozoa in spite of the fact that they provide potential targets for the development of new therapy. The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidence also points to autophagy as a mediator of death in certain physiological contexts. Bioinformatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa possess the capacity for PCD including a primordial form of apoptosis. Recent work in . Toxoplasma and emerging data from . Plasmodium suggest that autophagy-related processes may serve as an additional death promoting pathway in Apicomplexa. Detailed mechanistic studies into the molecular basis for PCD in parasitic protozoa represent a fertile area for investigation and drug development.

KW - Apicomplexa

KW - Autophagy

KW - Plasmodium

KW - Programmed cell death (PCD)

KW - Toxoplasma

UR - https://www.scopus.com/pages/publications/84865171164

UR - https://www.scopus.com/pages/publications/84865171164#tab=citedBy

U2 - 10.1016/j.pt.2012.06.006

DO - 10.1016/j.pt.2012.06.006

M3 - Review article

C2 - 22819059

AN - SCOPUS:84865171164

SN - 1471-4922

VL - 28

SP - 358

EP - 364

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 9

ER -

Autophagy in Apicomplexa: A life sustaining death mechanism?

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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