Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.
|Number of pages||6|
|Journal||Experimental and Toxicologic Pathology|
|State||Published - Jul 2014|
Bibliographical noteFunding Information:
This work was supported by the American Cancer Society [ RSG-11-116-01-CNE to G.C.].
- Oxidative stress
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology