Autophagy in arsenic carcinogenesis

Yuanlin Qi, Hui Li, Mingfang Zhang, Tao Zhang, Jacqueline Frank, Gang Chen

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalExperimental and Toxicologic Pathology
Volume66
Issue number4
DOIs
StatePublished - Jul 2014

Bibliographical note

Funding Information:
This work was supported by the American Cancer Society [ RSG-11-116-01-CNE to G.C.].

Keywords

  • Arsenic
  • Autophagy
  • Carcinogenesis
  • Oxidative stress

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology

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