Autophagy in arsenic carcinogenesis

Yuanlin Qi; Hui Li; Mingfang Zhang; Tao Zhang; Jacqueline Frank; Gang Chen

doi:10.1016/j.etp.2014.01.004

Autophagy in arsenic carcinogenesis

Yuanlin Qi, Hui Li, Mingfang Zhang, Tao Zhang, Jacqueline Frank, Gang Chen

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.

Original language	English
Pages (from-to)	163-168
Number of pages	6
Journal	Experimental and Toxicologic Pathology
Volume	66
Issue number	4
DOIs	https://doi.org/10.1016/j.etp.2014.01.004
State	Published - Jul 2014

Bibliographical note

Funding Information:
This work was supported by the American Cancer Society [ RSG-11-116-01-CNE to G.C.].

Keywords

Arsenic
Autophagy
Carcinogenesis
Oxidative stress

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.etp.2014.01.004

Cite this

@article{8f48685015874eea83168a5852427f40,

title = "Autophagy in arsenic carcinogenesis",

abstract = "Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.",

keywords = "Arsenic, Autophagy, Carcinogenesis, Oxidative stress",

author = "Yuanlin Qi and Hui Li and Mingfang Zhang and Tao Zhang and Jacqueline Frank and Gang Chen",

note = "Funding Information: This work was supported by the American Cancer Society [ RSG-11-116-01-CNE to G.C.].",

year = "2014",

month = jul,

doi = "10.1016/j.etp.2014.01.004",

language = "English",

volume = "66",

pages = "163--168",

number = "4",

}

TY - JOUR

T1 - Autophagy in arsenic carcinogenesis

AU - Qi, Yuanlin

AU - Li, Hui

AU - Zhang, Mingfang

AU - Zhang, Tao

AU - Frank, Jacqueline

AU - Chen, Gang

N1 - Funding Information: This work was supported by the American Cancer Society [ RSG-11-116-01-CNE to G.C.].

PY - 2014/7

Y1 - 2014/7

N2 - Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.

AB - Chronic exposure to arsenic may cause cancer. Many mechanisms have been suggested for arsenic carcinogenesis. Autophagy, an evolutionarily conserved cellular catabolic mechanism, has been implicated in cancer biology. Although being claimed as a type of cell death, autophagy may actually serve as a cell self-defense mechanism. In this review article, current understandings of the mechanisms of arsenic carcinogenesis, functions of autophagy and the role of autophagy in arsenic carcinogenesis are discussed.

KW - Arsenic

KW - Autophagy

KW - Carcinogenesis

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84896726142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896726142&partnerID=8YFLogxK

U2 - 10.1016/j.etp.2014.01.004

DO - 10.1016/j.etp.2014.01.004

M3 - Review article

C2 - 24560536

AN - SCOPUS:84896726142

SN - 0940-2993

VL - 66

SP - 163

EP - 168

JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

IS - 4

ER -

Autophagy in arsenic carcinogenesis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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