Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.
|Number of pages
|Immunology and Cell Biology
|Published - Apr 2021
Bibliographical noteFunding Information:
This work was supported by the National Institute of Health Grant R01AI121180 and R21AI128325 to JS, and R01CA221867 to JMY and JS.
© 2020 Australian and New Zealand Society for Immunology, Inc.
- T cells.
ASJC Scopus subject areas
- Immunology and Allergy
- Cell Biology