Abstract
Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.
Original language | English |
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Pages (from-to) | 351-360 |
Number of pages | 10 |
Journal | Immunology and Cell Biology |
Volume | 99 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2021 |
Bibliographical note
Publisher Copyright:© 2020 Australian and New Zealand Society for Immunology, Inc.
Funding
This work was supported by the National Institute of Health Grant R01AI121180 and R21AI128325 to JS, and R01CA221867 to JMY and JS.
Funders | Funder number |
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National Institutes of Health (NIH) | R01CA221867, R21AI128325, R01AI121180 |
Keywords
- T cells.
- autophagy
- differentiation
- immunotherapy
- memory
- survival
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology