Autophagy in T-cell differentiation, survival and memory

Liqing Wang, Jugal Kishore Das, Anil Kumar, Hao Yun Peng, Yijie Ren, Xiaofang Xiong, Jin Ming Yang, Jianxun Song

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

Original languageEnglish
Pages (from-to)351-360
Number of pages10
JournalImmunology and Cell Biology
Volume99
Issue number4
DOIs
StatePublished - Apr 2021

Bibliographical note

Publisher Copyright:
© 2020 Australian and New Zealand Society for Immunology, Inc.

Funding

This work was supported by the National Institute of Health Grant R01AI121180 and R21AI128325 to JS, and R01CA221867 to JMY and JS.

FundersFunder number
National Institutes of Health (NIH)R01CA221867, R21AI128325, R01AI121180

    Keywords

    • T cells.
    • autophagy
    • differentiation
    • immunotherapy
    • memory
    • survival

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Cell Biology

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