Autoregulation of Cardiac L-type calcium channels

Jonathan Satin; Elizabeth A. Schroder

doi:10.1016/j.tcm.2010.02.009

Autoregulation of Cardiac L-type calcium channels

Jonathan Satin, Elizabeth A. Schroder

Research output: Contribution to journal › Review article › peer-review

8 Citations (SciVal)

Abstract

l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Trends in Cardiovascular Medicine
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/j.tcm.2010.02.009
State	Published - Nov 2009

Bibliographical note

Funding Information:
Supported by a grant from the National Institutes of Health HL-07491 (JS). The authors thank Dr Brian P Delisle for helpful comments.

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.tcm.2010.02.009

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title = "Autoregulation of Cardiac L-type calcium channels",

abstract = "l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.",

author = "Jonathan Satin and Schroder, {Elizabeth A.}",

note = "Funding Information: Supported by a grant from the National Institutes of Health HL-07491 (JS). The authors thank Dr Brian P Delisle for helpful comments.",

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T1 - Autoregulation of Cardiac L-type calcium channels

AU - Satin, Jonathan

AU - Schroder, Elizabeth A.

N1 - Funding Information: Supported by a grant from the National Institutes of Health HL-07491 (JS). The authors thank Dr Brian P Delisle for helpful comments.

PY - 2009/11

Y1 - 2009/11

N2 - l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

AB - l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

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DO - 10.1016/j.tcm.2010.02.009

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SN - 1050-1738

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JO - Trends in Cardiovascular Medicine

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ER -

Autoregulation of Cardiac L-type calcium channels

Abstract

Bibliographical note

ASJC Scopus subject areas

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