l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.
|Number of pages||4|
|Journal||Trends in Cardiovascular Medicine|
|State||Published - Nov 2009|
Bibliographical noteFunding Information:
Supported by a grant from the National Institutes of Health HL-07491 (JS). The authors thank Dr Brian P Delisle for helpful comments.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine